Brenda M Patterson

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BACKGROUND Atopic asthma is characterized by intermittent exacerbations triggered by exposure to allergen. Exacerbations are characterized by an acute inflammatory reaction in the airways, with recruitment of both innate and adaptive immune cells. These cell populations as well as soluble factors are critical for initiating and controlling the inflammatory(More)
Pelvic ring trauma is frequently associated with damage to many organ systems, including the vascular, genitourinary, nervous, reproductive, and intestinal systems. The orthopaedic treatment of these patients must incorporate the presence of these injured soft tissue structures and the physicians who are knowledgeable in the care of these anatomic regions(More)
RATIONALE T lymphocytes are important in the pathogenesis of allergic asthma. Costimulation through CD28 is critical for optimal activation of T cells, and inhibition of this pathway with CTLA4Ig has been shown to be effective in preventing airway inflammation and hyperresponsiveness in animal models of asthma. Abatacept, a humanized version of CTLA4Ig, has(More)
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