Brenda L. Moss

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The COOH-terminal S9-S10 tail domain of large conductance Ca(2+)-activated K(+) (BK) channels is a major determinant of Ca(2+) sensitivity (Schreiber, M., A. Wei, A. Yuan, J. Gaut, M. Saito, and L. Salkoff. 1999. Nat. Neurosci. 2:416-421). To investigate whether the tail domain also modulates Ca(2+)-independent properties of BK channels, we explored the(More)
S cells form a chain of electrically coupled neurons that extends the length of the leech CNS and plays a critical role in sensitization during whole-body shortening. This process requires serotonin, which acts in part by altering the pattern of activity in the S-cell network. Serotonin-containing axons and varicosities were observed in Faivre's nerve where(More)
Functional large-conductance Ca(2+)- and voltage-activated K(+) (BK) channels can be assembled from four alpha subunits (Slo1) alone, or together with four auxiliary beta1 subunits to greatly increase the apparent Ca(2+) sensitivity of the channel. We examined the structural features involved in this modulation with two types of experiments. In the first,(More)
The Ca2+-dependent gating mechanism of cloned BK channels from Drosophila (dSlo) was studied. Both a natural variant (A1/C2/E1/G3/IO) and a mutant (S942A) were expressed in Xenopus oocytes, and single-channel currents were recorded from excised patches of membrane. Stability plots were used to define stable segments of data. Unlike native BK channels from(More)
The N-methyl-D-aspartate receptor (NMDAR) is involved in a number of physiological and pathophysiological processes in vertebrates, but there have been few studies examining the role of invertebrate NMDA receptors. In the leech, pharmacological evidence suggests that NMDARs contribute to synaptic plasticity, but there has been no molecular identification of(More)
abstract The COOH-terminal S9–S10 tail domain of large conductance Ca 2 ϩ-activated K ϩ (BK) channels is a major determinant of Ca 2 ϩ sensitivity To investigate whether the tail domain also modulates Ca 2 ϩ-independent properties of BK channels, we explored the functional differences between the BK channel mSlo1 and another member of the Slo family, mSlo3(More)
Technology plays an important role in making a hospital's patients, staff, physicians and visitors feel safe. But there's also a human side to security. The staff that can boost your facility's security efforts are already right there 24/7: administrators, clerical and clinical staff, physicians, department operations personnel and even contractors. Their(More)
abstract Functional large-conductance Ca 2 ϩ-and voltage-activated K ϩ (BK) channels can be assembled from four ␣ subunits (Slo1) alone, or together with four auxiliary ␤ 1 subunits to greatly increase the apparent Ca 2 ϩ sensitivity of the channel. We examined the structural features involved in this modulation with two types of experiments. In the first,(More)
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