Brenda K. Weis

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To facilitate collaborative research efforts between multi-investigator teams using DNA microarrays, we identified sources of error and data variability between laboratories and across microarray platforms, and methods to accommodate this variability. RNA expression data were generated in seven laboratories, which compared two standard RNA samples using 12(More)
New technologies and methods for assessing human exposure to chemicals, dietary and lifestyle factors, infectious agents, and other stressors provide an opportunity to extend the range of human health investigations and advance our understanding of the relationship between environmental exposure and disease. An ad hoc Committee on Environmental Exposure(More)
Gene expression profiling is a widely used technique with data from the majority of published microarray studies being publicly available. These data are being used for meta-analyses and in silico discovery; however, the comparability of toxicogenomic data generated in multiple laboratories has not been critically evaluated. Using the power of prospective(More)
Background: The introduction of circular staplers into colorectal surgery has revolutionized anastomotic techniques stretching the limits of sphincter preservation. Data on the double-stapling technique (DST) has been widely published in the West where the incidence of colorectal cancer is high. However studies using this technique and their results, in the(More)
This is the report of the first workshop "Validation of Toxicogenomics-Based Test Systems" held 11-12 December 2003 in Ispra, Italy. The workshop was hosted by the European Centre for the Validation of Alternative Methods (ECVAM) and organized jointly by ECVAM, the U.S. Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM),(More)
Theodore Bammler1, Richard P Beyer1, Sanchita Bhattacharya2, Gary A Boorman3, Abee Boyles4, Blair U Bradford5, Roger E Bumgarner6, Pierre R Bushel7, Kabir Chaturvedi8, Dongseok Choi9, Michael L Cunningham3, Shibing Deng5, Holly K Dressman4, Rickie D Fannin7, Fredrico M Farin1, Jonathan H Freedman4, Rebecca C Fry2, Angel Harper8, Michael C Humble10, Patrick(More)
Large prospective cohort studies are critical for identifying etiologic factors for disease, but they require substantial long-term research investment. Such studies can be conducted as multisite consortia of academic medical centers, combinations of smaller ongoing studies, or a single large site such as a dominant regional health-care provider. Still(More)
The idea that nerve cells cannot be replenished was long regarded as fact, but experiments in the last few decades have overturned this misconception. Integral to this turnaround was a report that cells isolated from the adult mammalian central nervous system could, through cell division, produce large clonal spheres composed of daughter cells capable of(More)
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