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One year soy protein supplementation has positive effects on bone formation markers but not bone density in postmenopausal women
The findings suggest that although one year supplementation of 25 g protein per se positively modulated markers of bone formation, this amount of protein was unable to prevent lumbar and whole body bone loss in postmenopausal women.
Soy protein has a greater effect on bone in postmenopausal women not on hormone replacement therapy, as evidenced by reducing bone resorption and urinary calcium excretion.
- B. Arjmandi, D. A. Khalil, +4 authors R. Wild
- MedicineThe Journal of clinical endocrinology and…
- 1 March 2003
Results indicate that soy protein may positively influence bone and calcium homeostasis in postmenopausal women, particularly those not on HRT.
Dried Plum Polyphenols Inhibit Osteoclastogenesis by Downregulating NFATc1 and Inflammatory Mediators
- S. Bu, M. Lerner, +4 authors Brenda J. Smith
- Chemistry, MedicineCalcified Tissue International
- 29 May 2008
It is demonstrated that dried plum polyphenols directly inhibit osteoclastogenesis, leading to a decrease in osteOClast activity, by downregulating NFATc1 and inflammatory mediators.
Soy protein supplementation increases serum insulin-like growth factor-I in young and old men but does not affect markers of bone metabolism.
- D. A. Khalil, E. Lucas, S. Juma, Brenda J. Smith, M. Payton, B. Arjmandi
- Biology, MedicineThe Journal of nutrition
- 1 September 2002
The effects ofSP on serum IGF-I levels suggest that SP may positively influence bone in men, and longer-duration studies examining the effects of SP or its isoflavones on bone turnover and bone mineral density and content in men are warranted.
Dried plum polyphenols attenuate the detrimental effects of TNF-alpha on osteoblast function coincident with up-regulation of Runx2, Osterix and IGF-I.
- S. Bu, Tamara S Hunt, Brenda J. Smith
- Chemistry, MedicineThe Journal of nutritional biochemistry
It is concluded that dried plum polyphenols enhance osteoblast activity and function by up-regulating Runx2, Osterix and IGF-I and increasing lysyl oxidase expression, and at the same time attenuate osteoclastogenesis signaling.
Dietary polyphenols and mechanisms of osteoarthritis.
- C. Shen, Brenda J. Smith, +4 authors I. Kwun
- MedicineThe Journal of nutritional biochemistry
- 1 November 2012
The effects of commonly consumed polyphenols, including curcumin, epigallocatechin gallate and green tea extract, resveratrol, nobiletin and citrus fruits, pomegranate, as well as genistein and soy protein, on osteoarthritis are discussed with an emphasis on molecular antiosteoarthritic mechanisms.
Dried Plum’s Unique Capacity to Reverse Bone Loss and Alter Bone Metabolism in Postmenopausal Osteoporosis Model
Compared to other dried fruits in this study, dried plum was unique in its ability to down-regulate osteoclast differentiation coincident with up-regulating osteoblast and glutathione (GPx) activity, which provides insight into dried plum’s unique effects on bone.
Soy isoflavones' osteoprotective role in postmenopausal women: mechanism of action.
Ovarian hormone deficiency is a major risk factor for osteoporosis and a class of synthetic and naturally occurring compounds, selective estrogen receptor modulators, e.g. raloxifene and soy isoflavones can offer attractive alternatives.
Consumption of different sources of omega-3 polyunsaturated fatty acids by growing female rats affects long bone mass and microarchitecture.
- R. Lukas, J. Gigliotti, Brenda J. Smith, Stephanie N. Altman, J. Tou
- Chemistry, MedicineBone
- 1 September 2011
Results showed that rats fed TO, rich in docosahexaenoic acid (DHA, 22:6ω-3) had higher tibial bone mineral density and bone mineral content and lower lipid peroxidation compared to the CO-fed rats, and Serum osteocalcin was associated with improved trabecular bone microarchitecture.
Induction of cardiovascular pathology in a novel model of low-grade chronic inflammation.
- Brenda J. Smith, S. Lightfoot, +6 authors D. Brackett
- MedicineCardiovascular pathology : the official journal…
It is suggested that inflammation induced by chronic exposure to LPS produces cardiovascular pathology in the smaller intramural arteries and arterioles and support the utility of this model for further mechanistic and therapeutic studies focused on the role of chronic inflammation in cardiovascular disease.