Brenda E. S. Gibson

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In doing so it acknowledges changes in transfusion practice during the past decade, particularly in respect of safety issues and further published transfusion-related guidelines. The transfusion requirements of the neonate are recognized as unique, but there are other groups of children who are regularly transfused and who have very specific transfusion(More)
These guidelines address developmental aspects of neonatal haemostasis and thrombosis, the laboratory investigation of the neonate, and the diagnosis and clinical management of haemostatic and thrombotic conditions occurring in this period (defined as the first 4 weeks of life following birth). Relevant scientific papers were identified by a systematic(More)
IKAROS family zinc finger 1/IKZF1 is a transcription factor important in lymphoid differentiation, and a known tumor suppressor in acute lymphoid leukemia. Recent studies suggest that IKZF1 is also involved in myeloid differentiation. To investigate whether IKZF1 deletions also play a role in pediatric acute myeloid leukemia, we screened a panel of(More)
This paper presents a technique to expose and characterize nano-structured hole arrays in tapered photonic crystal fibers. Hole array structures are examined with taper outer diameters ranging from 12.9 microm to 1.6 microm. A combined focused ion beam milling and scanning electron microscope system was used to expose and characterize the arrayed air-silica(More)
(2015) X-ray diffraction computed tomography for structural analysis of electrode materials in batteries. Abstract Acute Myeloid Leukaemia (AML) is a heterogenous disease of haematopoietic stem and progenitor cells (HSCs/HSPCs). The pathogenesis of AML involves cytogenetic abnormalities, genetic mutations and epigenetic anomalies. Whilst it is widely(More)
et al. Oligoclonal protein bands and Ig isotype switching in multiple myeloma treated with high-dose therapy and hematopoi-etic cell transplantation. serum immunofixation patterns frequently emerge in immunomodulatory therapy and are associated with a high degree of response in multiple myeloma.mission is the most relevant prognostic factor for multiple(More)
We summarize the high-resolution science that has been done on high redshift galaxies with Adaptive Optics (AO) on the world's largest ground-based facilities and with the Hubble Space Telescope (HST). These facilities complement each other. Ground-based AO provides better light gathering power and in principle better resolution than HST, giving it the edge(More)
BACKGROUND The MRC UKALLXI trial tested the efficacy of different central nervous system (CNS) directed therapies in childhood acute lymphoblastic leukaemia (ALL). To evaluate morbidity 555/1826 randomised children underwent prospective psychological evaluations. Full Scale, verbal and performance IQs were measured at 5 months, 3 years and 5 years. Scores(More)
BACKGROUND Although GATA1 is one of the most extensively studied haematopoietic transcription factors little is currently known about the physiological functions of its naturally occurring isoforms GATA1s and GATA1FL in humans-particularly whether the isoforms have distinct roles in different lineages and whether they have non-redundant roles in(More)