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Niemann-Pick Type C disease (NPC) is a cholesterol storage disease with defects in the intracellular trafficking of exogenous cholesterol derived from low density lipoproteins. In NPC cases with a chronic progressive course, neurofibrillary tangles (NFTs) that consist of paired helical filaments (PHFs) have been reported. To determine if NPC tangles contain(More)
There is evidence that vascular endothelial growth factor (VEGF) contributes to solid tumor growth through the promotion of both angio-genesis and tumor vascular permeability. To abrogate VEGF signaling, we developed a small molecular weight inhibitor of VEGF receptor tyro-sine kinase (RTK) activity that was compatible with chronic oral administration.(More)
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