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Seventy-nine patients with unilateral frontal- or temporal-lobe excisions and 18 normal control subjects were tested on four self-ordered tasks requiring the organization of a sequence of pointing responses. There were two verbal and two nonverbal tasks. Patients wih excisions from the left frontal lobe exhibited significant impairments on all four tasks,(More)
We used positron emission tomography to investigate word generation in subjects whose first language was English but who were also proficient in French. These subjects performed three types of lexical search: rhyme generation based on phonological cues, synonym generation requiring a semantic search, and translation involving access to a semantic(More)
The recall of spatial location in patients with left or right temporal-lobe lesions was studied in two experiments, in which recall was tested either immediately after presentation of an array of objects, or after an intervening verbal task, a spatial task or an unfilled interval. Deficits were found only in patients with right temporal-lobe lesions that(More)
Cognitive Neuroscience Review and the Study of Memory that eventually led to the independent discipline of experimental psychology. In its early years, experimental psychology was concerned primarily with the study of sensation, but by the turn of the century the interests of psychologists turned to behavior itself—learning, Canada † Veterans Affairs(More)
Regional cerebral blood flow was measured with positron-emission tomography during two encoding and two retrieval tasks that were designed to compare memory for object features with memory for object locations. Bilateral increases in regional cerebral blood flow were observed in both anterior and posterior regions of inferior temporal cortex and in ventral(More)
Recall of words from categorised lists was examined in 77 patients and 12 normal control subjects. In Experiment 1, both left temporal-lobe excisions that included the hippocampus (LTH) and left frontal-lobe removals (LF) impaired free recall, but the LF group performed normally when encoding and retrieval strategies were supplied. In Experiment 2,(More)
Three recency-discrimination tasks (involving concrete words, representational drawings and abstract paintings) were administered to 117 patients who had undergone unilateral cortical removals, and to 20 normal control subjects. Frontal or anterior temporal-lobe excision did not impair simple item recognition, and neither left nor right anterior-temporal(More)
Abstract A plethora of studies, across many species, have now demonstrated that the hippocampal region plays a critical role in memory for spatial location. In spite of this compelling evidence, a number of important neuropsychological and neuroanatomical issues remain unresolved. In the present study, the functional anatomy of object-location memory was(More)
Past neuroimaging research has identified a parahippocampal place area (PPA) in the posterior medial temporal lobe (MTL), which responds preferentially to visual scenes and plays a role in episodic memory for this class of stimuli. In the present positron emission tomography study, we examined to what extent the functional characteristics of the PPA(More)