Breid O'Brien

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OBJECTIVE To determine in a Canadian health care setting the cost effectiveness of urate lowering drugs (ULD) in the treatment of nontophaceous gouty arthritis with recurrent attacks and to evaluate the least costly regimen among available ULD. METHODS A decision analysis model was designed using hypothetical cohort of patients who present 1 to 4(More)
There is a growing demand for economic evaluation of new therapeutic interventions to provide health care decision makers with information on the relative value for money offered by alternative treatments. We review the rationale for economic evaluation and distinguish between 4 analytic techniques: cost minimization analysis, cost effectiveness analysis,(More)
In this paper we present a novel neural network based behavioral level model for a microwave power amplifier (PA) utilizing a prior knowledge technique. Model parameters are extracted and verified using independent wideband digitally modulated signals in the time domain. Both quasi-memoryless and neural network models without any prior knowledge inputs are(More)
In this paper we introduce Mokap, a novel authoring and development toolset for serious games. Mokap aims to address two specific challenges: provide support for early development stage design and facilitate involvement of domain experts. More specifically, on the one hand, it aims to make serious game authoring possible for people with no technical(More)
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