Breid O'Brien

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  • G. Arcieri, R. August, +5 authors B. O'Brien
  • 1986
This interim analysis of the efficacy and safety of ciprofloxacin is based on case reports of 1241 adult patients treated primarily in the USA; 1026 were suitable for analysis of drug efficacy. The daily dose ranged from 500 to 1500 mg, the unit dose being given every 12 h. Duration of treatment ranged from 5 to 211 days (mean 12.6 days). In 1046 cases of(More)
OBJECTIVE To determine in a Canadian health care setting the cost effectiveness of urate lowering drugs (ULD) in the treatment of nontophaceous gouty arthritis with recurrent attacks and to evaluate the least costly regimen among available ULD. METHODS A decision analysis model was designed using hypothetical cohort of patients who present 1 to 4(More)
There is a growing demand for economic evaluation of new therapeutic interventions to provide health care decision makers with information on the relative value for money offered by alternative treatments. We review the rationale for economic evaluation and distinguish between 4 analytic techniques: cost minimization analysis, cost effectiveness analysis,(More)
In this paper we present a novel neural network based behavioral level model for a microwave power amplifier (PA) utilizing a prior knowledge technique. Model parameters are extracted and verified using independent wideband digitally modulated signals in the time domain. Both quasi-memoryless and neural network models without any prior knowledge inputs are(More)
In this paper we introduce Mokap, a novel authoring and development toolset for serious games. Mokap aims to address two specific challenges: provide support for early development stage design and facilitate involvement of domain experts. More specifically, on the one hand, it aims to make serious game authoring possible for people with no technical(More)
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