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Central nervous system (CNS) prophylaxis involving cranial irradiation has frequently been found to result in cognitive deficits in survivors of childhood acute lymphoblastic leukaemia. The existence of this effect is still controversial, however, as is the question of factors that might affect its severity. The literature is surveyed and a meta-analysis(More)
This study compares the incidence of a variety of cutaneous conditions among 91 patients treated with lithium carbonate with the incidence of such conditions among 44 patients treated with other non-neuroleptic, maintenance medications. Data on cutaneous conditions and allergies were obtained using structured interviews, demographic data, medication(More)
Chronic diseases present a growing challenge to women's health. This paper presents data from the Australian Longitudinal Study on Women's Health to show prevalence and incidence among three cohorts of women of six chronic conditions: hypertension, heart disease, diabetes, asthma, osteoporosis and arthritis. It also examines the role of five important risk(More)
We assessed neuropsychologically 106 children with acute lymphoblastic leukemia (ALL) who had all received cranial irradiation for the prevention of central nervous system (CNS) leukemia 1-13 years previously. Children were assessed for adverse late effects of their therapy, using age-appropriate Wechsler measures of overall intellectual ability and(More)
Forty-eight of the 50 living adult offspring of 16 bipolar patients were interviewed. Data was available on the 2 other offspring, who had previously suicided. One half of the offspring met criteria for psychiatric illness, the majority of which was either primary affective or other affective disorder. The mean age of onset of illness was middle to late(More)
A group of 29 bipolar manic-depressives completed a 12-month double-blind cross-over trial of low-dose and high-dose lithium prophylaxis. Twelve patients relapsed, and significantly more of the relapses occurred during the low-dose 6-month phase of the trial. There was a trend for relapse to occur within 2 months of an abrupt drop in plasma lithium level,(More)
Fifty-five of the 58 adult offspring of 17 bipolar manic-depressives were studied. Fifty-three were interviewed and some data were available on the two who had committed suicide. A detailed educational history and pregnancy and birth (paranatal) history were obtained and were corroborated by records where available. Thirty-two percent of the offspring met(More)