Breanne Johnsen

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BACKGROUND Although several agents are available to treat osteoporosis, the relative efficacy and toxicity of these agents when used to prevent fractures has not been well described. PURPOSE To compare the benefits in fracture reduction and the harms from adverse events of various therapies for osteoporosis. DATA SOURCES MEDLINE (1966 to November 2007)(More)
CONTEXT Probiotics are live microorganisms intended to confer a health benefit when consumed. One condition for which probiotics have been advocated is the diarrhea that is a common adverse effect of antibiotic use. OBJECTIVE To evaluate the evidence for probiotic use in the prevention and treatment of antibiotic-associated diarrhea (AAD). DATA SOURCES(More)
OBJECTIVES To systematically document the implementation, components, comparators, adherence, and effectiveness of published fall prevention approaches in U.S. acute care hospitals. DESIGN Systematic review. Studies were identified through existing reviews, searching five electronic databases, screening reference lists, and contacting topic experts for(More)
CONTEXT Acute Otitis Media (AOM), a viral or bacterial infection of the ear, is the most common childhood infection for which antibiotics are prescribed in the United States. In 2001, the Southern California Evidence-based Practice Center conducted a systematic review of the evidence comparing treatments of AOM. OBJECTIVES This review updates the 2001(More)
BACKGROUND Systematic reviews are a cornerstone of evidence-based medicine but are useful only if up-to-date. Methods for detecting signals of when a systematic review needs updating have face validity, but no proposed method has had an assessment of predictive validity performed. METHODS The AHRQ Comparative Effectiveness Review program had produced 13(More)
OBJECTIVES To catalog what is known about the safety of interventions containing Lactobacillus, Bifidobacterium, Saccharomyces, Streptococcus, Enterococcus, and/or Bacillus strains used as probiotic agents in research to reduce the risk of, prevent, or treat disease. DATA SOURCES We searched 12 electronic databases, references of included studies, and(More)
1 Southern California Evidence Based Practice Center, Rand Health, Santa Monica, California, United States of America, 2 Agency for Healthcare Research and Quality, Rockville, Maryland, United States of America, 3 National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America, 4 West Los(More)
BACKGROUND There is an increasing push for 'evidence-based' decision making in global health policy circles. However, at present there are no agreed upon standards or guidelines for how to evaluate evidence in global health. Recent evaluations of existing evidence frameworks that could serve such a purpose have identified details of program context and(More)
The findings and conclusions in this document are those of the author(s), who are responsible for its contents; the findings and conclusions do not necessarily represent the views of AHRQ. Therefore, no statement in this report should be construed as an official position of AHRQ or of the U.S. Department of Health and Human Services. The information in this(More)