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Genetic studies of body mass index yield new insights for obesity biology
TLDR
A genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals provide strong support for a role of the central nervous system in obesity susceptibility.
New genetic loci link adipose and insulin biology to body fat distribution
TLDR
A genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms.
Population genetic differentiation of height and body mass index across Europe
TLDR
It is found that many independent loci contribute to population genetic differences in height and body mass index in 9,416 individuals across 14 European countries.
Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases: A Mendelian Randomization Study
TLDR
It is likely that longer telomeres increase risk for several cancers but reduce risk for some non-neoplastic diseases, including cardiovascular diseases, as well as single nucleotide polymorphisms (SNPs) that are strongly associated with telomere length in the general population.
Rare and low-frequency coding variants alter human adult height
TLDR
The results demonstrate that sufficiently large sample sizes can uncover rare and low-frequency variants of moderate-to-large effect associated with polygenic human phenotypes, and that these variants implicate relevant genes and pathways.
Insights from Genome-Wide Association Analyses of Nonalcoholic Fatty Liver Disease.
TLDR
This work has shown that genome-wide association studies have discovered genetic variants that associate with nonalcoholic fatty liver disease that cannot only help to identify individuals at high risk of developing NAFLD, but also to better understand its pathophysiology so that more effective treatments for this disease and related metabolic diseases in the future are developed.
Gene-based meta-analysis of genome-wide association studies implicates new loci involved in obesity.
TLDR
The results indicate that gene-based meta-analysis of GWAS provides a useful strategy to find loci of interest that were not identified in standard single-marker analyses due to high allelic heterogeneity.
Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure underpinning obesity
TLDR
Exome-wide analysis identifies rare and low-frequency coding variants associated with body mass index that confirm enrichment of neuronal genes and provide new evidence for adipocyte and energy expenditure biology, widening the potential of genetically supported therapeutic targets in obesity.
PROTEIN-CODING VARIANTS IMPLICATE NOVEL GENES RELATED TO LIPID HOMEOSTASIS CONTRIBUTING TO BODY FAT DISTRIBUTION
TLDR
A transancestral exome-wide association study for body-fat distribution identifies protein-coding variants that are significantly associated with waist-to-hip ratio adjusted for body mass index.
Characterization of european ancestry nonalcoholic fatty liver disease‐associated variants in individuals of african and hispanic descent
TLDR
Multiple genetic variants are associated with hepatic steatosis across ancestries, which explains a substantial proportion of the genetic predisposition in African‐ and Hispanic‐Americans.
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