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- Adam E Locke, Bratati Kahali, +479 authors Elizabeth K. Speliotes
- Nature
- 2015
Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass… (More)
- Dmitry Shungin, Thomas W. Winkler, +403 authors Karen L. Mohlke
- Nature
- 2015
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body… (More)
- Matthew R Robinson, Gibran Hemani, +40 authors Peter M. Visscher
- Nature Genetics
- 2015
Across-nation differences in the mean values for complex traits are common, but the reasons for these differences are unknown. Here we find that many independent loci contribute to population genetic… (More)
- Eirini Marouli, Mariaelisa Graff, +368 authors Guillaume Lettre
- Nature
- 2017
Height is a highly heritable, classic polygenic trait with approximately 700 common associated variants identified through genome-wide association studies so far. Here, we report 83 height-associated… (More)
- Bratati Kahali, Brian Halligan, Elizabeth K. Speliotes
- Seminars in liver disease
- 2015
Nonalcoholic fatty liver disease (NAFLD) is caused by hepatic steatosis, which can progress to nonalcoholic steatohepatitis, fibrosis/cirrhosis, and hepatocellular carcinoma in the absence of… (More)
- Aaron P Thrift, Jian Gong, +39 authors Peter T. Campbell
- Cancer epidemiology, biomarkers & prevention : a…
- 2015
BACKGROUND
High body mass index (BMI) is consistently linked to increased risk of colorectal cancer for men, whereas the association is less clear for women. As risk estimates from observational… (More)
- Bratati Kahali, Yang-Lin Liu, Ann K Daly, Christopher Paul Day, Quentin M Anstee, Elizabeth K. Speliotes
- Gastroenterology
- 2015
onalcoholic fatty liver disease N(NAFLD) is rapidly becoming the most common cause of chronic liver disease worldwide. NAFLD includes a spectrum of disease ranging from the accumulation of fat in the… (More)
Gene-based meta-analysis of genome-wide association studies implicates new loci involved in obesity.
- Sara Hägg, Andrea Ganna, +15 authors Erik Ingelsson
- Human molecular genetics
- 2015
To date, genome-wide association studies (GWASs) have identified >100 loci with single variants associated with body mass index (BMI). This approach may miss loci with high allelic heterogeneity;… (More)
- Philip C. Haycock, Stephen Burgess, +195 authors George Davey Smith
- JAMA oncology
- 2017
Importance
The causal direction and magnitude of the association between telomere length and incidence of cancer and non-neoplastic diseases is uncertain owing to the susceptibility of observational… (More)
- V Turcot, Yingchang Tang Lu, +396 authors Ruth J F Loos
- Nature Genetics
- 2018
In the version of this article originally published, one of the two authors with the name Wei Zhao was omitted from the author list and the affiliations for both authors were assigned to the single… (More)