Branko S. Jursic

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Andrew H. Rodgers1
Robert F. Struck1
Lee Roy Morgan1
Blaise LeBlanc1
1Andrew H. Rodgers
1Robert F. Struck
1Lee Roy Morgan
1Blaise LeBlanc
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PURPOSE The purpose of this investigation was to synthesize a series of carbonate and carbamate derivatives of 4-demethylpenclomedine (DM-PEN), the major plasma non-toxic metabolite of penclomedine (PEN) seen in patients. DM-PEN has been observed to be an active antitumor agent in mouse human xenograft tumor models and non-neurotoxic in a rat model,(More)
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