Branka Čučević

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BACKGROUND Several studies have shown the efficacy, tolerability, and ease of administration of pemetrexed-an antifolate antineoplastic agent-in patients with advanced non-small-cell lung cancer. We assessed pemetrexed as maintenance therapy in patients with this disease. METHODS This randomised double-blind study was undertaken in 83 centres in 20(More)
PURPOSE The primary objective of this randomized phase III study was to show significant difference in median time to progression (TTP) in patients with advanced NSCLC treated with single-agent gemcitabine maintenance therapy versus best supportive care following gemcitabine plus cisplatin initial first-line therapy. PATIENTS AND METHODS Chemonaive(More)
BACKGROUND Pemetrexed maintenance therapy significantly improved overall survival and progression-free survival compared with placebo, and had a good safety profile in a phase 3 placebo-controlled study in patients with advanced non-small-cell lung cancer (NSCLC). Results for quality of life, symptom palliation, and tolerability are presented here. (More)
Waist circumference is a good predictor of the risk of heart diseases, but data on the relationship between waist circumference and pulmonary diseases are sparse. The aim of this study was to investigate its influence on pulmonary function regarding exercise capacity in moderate and severe chronic obstructive pulmonary disease (COPD), according to Global(More)
AIM (1001 Dalmatians) research program collects biomedical information from multiple small isolated populations ((metapopulation)) on Adriatic islands, Croatia, and investigates health effects of human population isolation, inbreeding, admixture, and outbreeding. METHODS We collected random samples of 100 individuals from 9 island settlements and an(More)
This study was carried out in 59 patients with histological evidence of pulmonary sarcoidosis. In all patients, bronchoalveolar lavage (BAL) and transbronchial biopsy (TBB) were performed simultaneously. In histologic specimens of TBB, 24/59 (41%) patients had luminal alveolitis, 36/59 (61%) mural alveolitis, 41/59 (69%) granulomas 11/59 (15%) diffuse(More)
7067 Background: The optimal treatment duration for NSCLC patients is still a matter of discussion. Objectives of this trial were to compare time to progressive disease (TTPD) in patients treated with single-agent gemcitabine maintenance therapy plus best supportive care (BSC) versus BSC alone following standard GC therapy, to record responses in both arms,(More)
Aim of this study was to estimate efficacy of gemcitabine in first and the second-line chemotherapy for patients with advanced non-small cell lung cancer (stage III and IV). In first-line chemotherapy, 120 patients were treated with different chemotherapy regimens. Fifty-nine patients were treated with gemcitabine / cisplatin (PG), 41 with cisplatin /(More)
The aim of this study is to investigate whether there was a considerable difference in the survival of patients with malignant pleural effusion (MPE) depending on the pleural effusion treatment option. One hundred and seven patients with proven MPE (metastatic lung and breast cancer) were included in the retrospective study. Fifty six patients were treated(More)
Stress cardiomyopathy following acute ischemic stroke during flexible bronchoscopy: a rare sequence of complications Cardiomiopatia induzida por stress após acidente vascular cerebral isquêmico agudo durante broncoscopia flexível: uma rara sequência de complicações Flexible bronchoscopy is a routine procedure used in a wide spectrum of airway pathologies,(More)