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This study was aimed to evaluate resveratrol (1-100 μM) effect on the spontaneous rhythmic contractions (SRC), oxytocin-induced (0.2 nM, POxC) phasic and tonic (20 nM, TOxC) contractions of isolated rat uterus. The SRC and POxC were more sensitive to resveratrol than TOxC (pD2 values: 4.53 and 4.66 versus 4.06). Different blockers of K(+) channels… (More)
A case of floppy eyelid syndrome associated with keratotorus is presented. The patient was thoroughly examined and followed up for several years. During that time he developed an acute corneal hydrops. The importance of this association for the better understanding of the syndrome is discussed.
INTRODUCTION Association studies have shown that gene polymorphisms in various classes of genes can modulate cancer risk. The -31G/C polymorphism in the promoter of survivin gene, affects the expression of the anti-apoptotic protein survivin which in turn may predispose an individual to some types of cancer. OBJECTIVE The aim of the study was to determine… (More)
BACKGROUND Polymorphisms in genes encoding tumor necrosis factor-α (TNF-α) and its receptor TNF-R1 have been shown to affect one person's susceptibility to develop certain neoplastic diseases. The aim of the present association study was to investigate whether single nucleotide polymorphisms (SNPs) in TNF-α (-308G>A) and TNF-R1 (36A>G) genes modulate the… (More)
The ideal agent for prevention and treatment of uterine abnormal contractility has not been found. The polyphenol resveratrol possesses a wide spectrum of pharmacologic properties, but its influence on the contractility of human myometrium is not defined. The present study evaluated the effect of resveratrol on the oxytocin-induced contractions of human… (More)
Ophthalmopathy of Graves-Basedow disease appears in 20-50% of patients suffering from thyreotoxicosis. It is usually bilateralophthalmopathy with different degrees of severity. Many noninvasive diagnostical methods are used today. In diagnostic procedure, and especially in therapy, multidisciplinary approaches are compulsory. Although therapeutical effects… (More)