Branimir Radmanović

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Small doses of prostaglandin E2 (0.3, 0.6 and 0.9 ng/ml) and prostaglandin F2alpha (0.25, 0.5 and 0.75 ng/ml) significantly potentiated the responses of the guinea-pig isolated ileum to cholinergic substances, i.e. acetylcholine, methacholine, carbachol and pilocarpine. All substances were applied from the serosal surface of the guinea-pig isolated ileum.(More)
INTRODUCTION In the last decades psychiatric patients' quality of life attracts great attention of researchers. Improving the quality of life of schizophrenic patients is increasingly becoming an imperative in pharmacological therapy. OBJECTIVE Analysis of certain aspects of quality of life in patients with schizophrenia treated with depot formulations of(More)
Intra-arterial injections of substance p in doses from 10 to 30 units potentiated the response of the nictitating membrane to submaximal stimulation of the preganglionic sympathetic nerve, while higher doses (30 to 100 units) usually depressed the response. The stimulating action of acetylcholine on the superior cervical ganglion (as judged by the response(More)
We investigated the inhibitory effect of nifedipine on contractile responses of the longitudinal and circular muscle of the isolated guinea-pig ileum. Nifedipine in very low concentrations, ranging from picomolar to nanomolar, inhibits the phasic and the tonic contractile responses of the longitudinal muscle induced by various agonists (histamine,(More)
1. The contractile response of the chronically denervated tongue of the cat to chorda stimulation, and to close arterial injections of bradykinin, acetylcholine (ACh) and other drugs was examined.2. Bradykinin in doses of 50 ng-20 mug injected close arterially always produced a contractile response of the denervated tongue. Sodium nitrite (1 mg i.a.) and(More)
To accomplish therapeutic goal it is necessary to adjust the dose of medication to be right for every single patient. This procedure of dose adjustment is individualized dose regimen. First of all, pharmacokinetic aspects should be revised, including parameters such as resorption, distribution, metabolism and secretion of drug. For these purposes, the(More)