Branimir Radmanović

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To accomplish therapeutic goal it is necessary to adjust the dose of medication to be right for every single patient. This procedure of dose adjustment is individualized dose regimen. First of all, pharmacokinetic aspects should be revised, including parameters such as resorption, distribution, metabolism and secretion of drug. For these purposes, the(More)
We investigated the inhibitory effect of nifedipine on contractile responses of the longitudinal and circular muscle of the isolated guinea-pig ileum. Nifedipine in very low concentrations, ranging from picomolar to nanomolar, inhibits the phasic and the tonic contractile responses of the longitudinal muscle induced by various agonists (histamine,(More)
Activity of the circular muscle of the isolated guinea-pig ileum in response to prostaglandin E2 (PGE2), acetylcholine (Ach), 5-hydroxytryptamine (5-HT) and dimethylphenylpiperazinium (DMPP) was investigated. PGE2 produced concentration-dependent rhythmic contractions of the circular muscle superimposed on an increased tone. Ach, 5-HT and DMPP also produced(More)
Prostaglandins E2 and F2 alpha at small concentrations inhibit the acetylcholinesterase activity in slices of caudate nucleus, thalamus and hypothalamus of the cat brain in vitro condition. Prostaglandin E2 (PGE2) at concentrations of 0.35 microM and 0.70 microM produces a dose-dependent inhibition of acetylcholinsteratse activity in slices of caudate(More)
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