Branimir Šimić

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The effects of atrazine exposure on testicular sperm number, epididymal sperm number and motility and alpha-glucosidase activity in the epididymis were studied in Fischer rats. Histological changes in the testicular tissue were followed by light and electron microscopy. Groups of adult animals were treated i.p. with 60 and 120 mg atrazine kg(-1) body wt.(More)
Concentrations of cadmium, mercury and lead were analysed by atomic absorption spectrometry in the kidney and muscle of free-living wild boar (n = 169) from hunting grounds in seven counties of continental Croatia. Mean levels of metals (mg/kg) in muscle and kidney of boars ranged as follows: Cd: 0.005-0.016 and 0.866-4.58, Pb: 0.033-0.15 and 0.036-0.441,(More)
The metabolism of 4-[4-14C]androstene-3,17-dione was studied in the microsomal fraction of rat livers after continuous administration of human GH (hGH) in Alzet osmotic minipumps under varying conditions. hGH caused a complete feminization of hepatic steroid metabolism (i.e. increased the 5 alpha-reductase and decreased the 6 beta- and 16 alpha-hydroxylase(More)
The effect of gamma-1,2,3,4,5,6-hexachlorocyclohexane (lindane), 2-chloro-4-ethylamino-6-isopropylamino-s-triazine (atrazine) and 2-methylthio-4,6-bis-isopropylamino-s-triazine (prometryne) on the formation of a specific oestradiol-receptor complex in the rat uterus cytosol has been examined in vitro and in vivo. Both in vitro and in vivo, the pesticides(More)
The concentration and relations of Cd and Pb as environmental risk factors were studied by atomic absorption spectrophotometry in the liver, kidney and muscle of free ranging wild boar (n=94) and red deer (n=45) from hunting grounds in four counties of north-east Croatia. In all four counties, the levels of Cd found in the kidney of red deer ranged from(More)
The effects of subacute exposure to atrazine on body weight, ovarian cycling, conception rate and the size of litters in Fischer strain rats were studied. An atrazine dose of 120 mg kg-1 body wt given p.o. daily for 7 days to both female and male rats caused statistically significant loss of body weight in both sexes during the period of treatment. After(More)
The aim of this study was to determine the toxic effect of atrazine at the ovarian cellular level. Chinese Hamster Ovary (CHO-K1) cell line was used to evaluate the degree of in vitro atrazine cytotoxicity and the morphological changes were followed during the cell death. Application of four bioassays confirmed that atrazine decreases ovarian cell(More)
Lead concentrations were analysed by atomic absorption spectrometry in multifloral honeys collected in central Croatia (Zagreb County) during a three-year period from 2009 to 2011. The mean levels of elements (μg/kg) in honey samples measured were: 90.8 in 2009, 189 in 2010 and 360 in 2011. Significant differences were observed, and Pb levels determined in(More)
The effects of gamma-1,2,3,4,5,6-hexachlorocyclohexane (lindane) and O,O-dimethyl-S-(1,2-dicarbethoxyethyl)phosphorodithioate (malathion) on testosterone metabolism in rat prostate tissue in vitro was investigated. The influence of lindane on the formation of 5alpha-androstan-17beta-ol-3-one (5alpha-DHT)-receptor complex in the rat prostatic cytosol has(More)