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Role of J Chain in Secretory Immunoglobulin Formation
TLDR
The joining (J) chain is a small polypeptide, expressed by mucosal and glandular plasma cells, which regulates polymer formation of immunoglobulin (Ig)A and IgM, and both the J chain and the pIgR/SC are key proteins in secretory immunity. Expand
Lack of SC/pIgR‐mediated epithelial transport of a human polymeric IgA devoid of J chain: in vitro and in vivo studies
TLDR
Comparisons of human polymeric IgA myeloma proteins of tetrameric size and in vitro secretory component (SC)‐binding ability and capacity to be transcytosed by polymeric immunoglobulin receptor (pIgR)‐expressing epithelial cells in vitro and rat hepatocytes in vivo confirm the proposed key role of J chain in the epithelial transport of polymeric Immunoglobulins into exocrine secretions. Expand