• Publications
  • Influence
The heterotrimeric kinesin-2 complex interacts with and regulates GLI protein function
TLDR
Structural-function analyses suggest that GLI interactions with KIF3A–KIF3B–KAP3–KAB3 complexes are essential for proper GLI transcriptional activity. Expand
Identification and embryonic expression of a highly conserved Meis-linked gene
TLDR
During zebrafish development, transcripts of m2lg are observed in every cell of the embryo from the earliest stage through the shield stage indicating this gene is a maternal transcript since its expression precedes the activation of the zygotic genome at the midblastula transition. Expand
Identification and Developmental Expression of the Zebrafish ZGC:154061 Gene, a Conserved Yet Uncharacterized Maternally Expressed MEIS2 Linked Gene
TLDR
During zebrafish development, transcripts of zgc:154061 are observed in every cell of the embryo from the earliest stage through the shield stage indicating this gene is a maternal transcript since its expression precedes the activation of the zygotic genome at the midblastula transition. Expand
An ancient yet flexible cis-regulatory architecture allows localized Hedgehog tuning by patched/Ptch1
TLDR
This structure—one of the oldest cis-regulatory features discovered in animal genomes—explains how patched/Ptch1 can drive dramatic adaptations in animal morphology while maintaining its essential core function and may also suggest a general model for the evolutionary flexibility of conserved regulators and pathways. Expand
Repressive H3K9me2 protects lifespan against the transgenerational burden of COMPASS activity in C. elegans
TLDR
It is proposed that transcription-coupled H3K4me via COMPASS limits lifespan by encroaching upon domains of heterochromatin in the genome. Expand
Developing Future Biologists: creating and assessing a portable short course to engage underrepresented undergraduate students in developmental biology
TLDR
The DFB portable short course model is an easily adaptable tool that connects undergraduate students with opportunities for advanced study and lowers barriers for underrepresented students in science, technology, engineering, and mathematics. Expand
Caenorhabditis elegans establishes germline versus soma by balancing inherited histone methylation
TLDR
Maternally deposited histone-modifying enzymes prevent the ectopic expression of germline genes in somatic tissues and developmental delay by regulating the inheritance of histone methylation. Expand
Failure to maternally reprogram histone methylation causes developmental delay due to germline transcription in somatic tissues
TLDR
Spr-5; met-2 mutant progeny have a severe developmental delay that is associated with the ectopic maintenance of H3K36me2/3 at MES-4 targeted germline genes in somatic tissues, and the ectopy expression of these genes. Expand
CoREST has a conserved role in facilitating SPR-5/LSD1 maternal reprogramming of histone methylation
TLDR
Maternal LSD1 in the oocyte is derived exclusively from this allele, the progeny phenocopy the increased perinatal lethality that was observed when LSD1 was reduced maternally, consistent with CoREST having a conserved function in facilitating maternal LSD1 epigenetic reprogramming. Expand
...
1
2
...