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Genetic deficits and loss of function for the triggering receptor expressed in myeloid cells 2 (TREM2; encoded at chr6p21.1), a transmembrane spanning stimulatory receptor of the immunoglobulin/lectin-like gene superfamily, have been associated with deficiencies in phagocytosis and the innate immune system in Alzheimer's disease. In this study, we provide(More)
Amyloid is a generic term for insoluble, often intensely hydrophobic, fibrous protein aggregates that arise from inappropriately folded versions of naturally-occurring polypeptides. The abnormal generation and accumulation of amyloid, often referred to as amyloidogenesis, has been associated with the immune and pro-inflammatory pathology of several(More)
Inducible microRNAs (miRNAs) perform critical regulatory roles in central nervous system (CNS) development, aging, health, and disease. Using miRNA arrays, RNA sequencing, enhanced Northern dot blot hybridization technologies, Western immunoblot, and bioinformatics analysis, we have studied miRNA abundance and complexity in Alzheimer's disease (AD) brain(More)
Amyloidogenesis, the progressive accumulation of amyloid-beta (Aβ) peptides into insoluble, toxic, senile plaque lesions is one of the major defining features of the Alzheimer's disease (AD) brain. Normally, Aβ42 peptides are cleared from the extracellular space by natural phagocytic mechanisms, but when this intrinsic sensing and clearance system is(More)
Evolution of reactive oxygen species (ROS), generated during the patho-physiological stress of nervous tissue, has been implicated in the etiology of several progressive human neurological disorders including Alzheimer's disease (AD) and amylotrophic lateral sclerosis (ALS). In this brief communication we used mixed isomers of(More)
AIM To assess plasma zinc and copper concentration in individuals with autism and correlate these levels with symptom severity. SUBJECTS AND METHODS Plasma from 102 autistic individuals, and 18 neurotypical controls, were tested for plasma zinc and copper using inductively-coupled plasma-mass spectrometry. Copper and zinc levels and Cu/Zn were analyzed(More)
With the extirpation of apex predators from many North American systems, coyotes Canis latrans have become the de facto top predator and are ubiquitous members of most ecosystems. Keystone predators aid in maintaining ecosystem function by regulating the mammal community through direct predation and instilling the landscape of fear, yet the value of coyotes(More)
—The fusion of independently obtained stochastic maps by collaborating mobile agents is considered. The proposed approach includes two parts: generalized likehood ratio matching and maximum likelihood alignment. In particular, an affine invariant hypergraph model is constructed for each stochastic map and a bipartite matching via a linear program is used to(More)
In this paper, we consider the agreement problem of estimating the locations of landmarks observed by multiple agents in the absence of a global frame of reference. Maximum likelihood estimators are derived from scenarios of independent and mutual landmark estimation. A triangle-based hypothesis test is proposed for the detection of common landmarks across(More)