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Copper Acquisition and Utilization in Fungi.
Fungal pathogens have evolved mechanisms to acquire copper to successfully colonize the host, disseminate to other tissues, and combat host copper bombardment mechanisms that would otherwise mitigate virulence. Expand
Cathepsin Protease Controls Copper and Cisplatin Accumulation via Cleavage of the Ctr1 Metal-binding Ectodomain*♦
These studies identify a new processing event and the key protease that cleaves the Ctr1 metal-binding ectodomain, which functions to regulate cellular Cu+ and cisplatin acquisition. Expand
A Symphony of Cyclases : Specificity in Diguanylate Cyclase Signaling
Cyclic diguanylate (c-di-GMP) is a near universal signaling molecule produced by diguanylate cyclases that can direct a variety of bacterial behaviors. A major area of research over the last severalExpand
X-ray structures of the high-affinity copper transporter Ctr1
X-ray crystal structures of Ctr1 from Salmo salar are presented, revealing a homo-trimeric Cu+-selective ion channel-like architecture, which provides a high resolution picture to understand Cu+ import across cellular membranes and suggest therapeutic opportunities for intervention in diseases characterized by inappropriate Cu accumulation. Expand
Gene duplication and neo-functionalization in the evolutionary and functional divergence of the metazoan copper transporters Ctr1 and Ctr2
Key structural aspects of metazoan Ctr1 and Ctr2 are suggested that discriminate between their biological roles, providing mechanistic insights into the evolutionary, biochemical, and functional relationships between these two related proteins. Expand
A possible role of Reproductive Homeobox 6 in primordial germ cell differentiation.
It is suggested with these results that Rhox6 is necessary for determination of the germ cell lineage. Expand
Ctr2 Regulates Mast Cell Maturation by Affecting the Storage and Expression of Tryptase and Proteoglycans
Ctr2 and Cu are introduced as novel actors in the regulation of mast cell maturation and granule homeostasis by investigating the impact of Ctr2 deficiency on mast cells, a cell type unusually rich in endolysosomal organelles (secretory granules). Expand
A synthetic biological approach to reconstitution of inositide signaling pathways in bacteria.
Heterologous expression of inositide pathways in bacteria provide a malleable experimental platform for aiding signaling biologists and offers new insights into metabolism of these essential pathways. Expand
The Critical Roles of Polysaccharides in Gut Microbial Ecology and Physiology
The human intestine harbors a dense microbial ecosystem (microbiota) that is different between individuals, dynamic over time, and critical for aspects of health and disease. Dietary polysaccharidesExpand