Brandon C Wadas

Learn More
Hypothalamic GnRH neurons are essential for initiation and regulation of reproductive function. In addition to pituitary gonadotrope stimulation, activity of GnRH through its receptor (GnRHR) has been suggested to include autocrine regulation of the GnRH neuron. Two hypogonadal mouse strains, the Gnrh1 mutant (hpg) mice and Gnrhr mutant mice were used to(More)
Developmental exposure to the agricultural fungicide vinclozolin can impair reproductive function in male rabbits and was previously found to decrease the number of immunoreactive-gonadotrophin-releasing hormone (GnRH) neurones in the region of the organum vasculosum of the lamina terminalis and rostral preoptic area by postnatal week (PNW) 6. In the(More)
The history of studies of mechanisms of estrogen action in the brain is filled with at least two periods of intense dogmatic beliefs. These include thinking that a single type of cytoplasmic, unliganded estrogen receptor (ER) bound li-gand and moved to the nucleus after activation (1), to thinking that all ERs were located in cell nuclei even in the(More)
  • 1