Bradley de Vries

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We report on clinical and cytogenetic data on 5 children and 2 adults with a de novo inverted duplication of the short arm of chromosome 8, and we give a review of 26 patients from the literature. The clinical picture in young children is characterized by minor facial anomalies, hypotonia, and severe developmental delay. In older patients the facial traits(More)
OBJECTIVES To assess the impact of occipito-posterior position in the second stage of labour on operative delivery. METHODS Double-blinded prospective cohort study of ultrasound determined occiput-posterior position during the second stage of labour compared with occiput-anterior position. The primary outcome was operative (caesarean section, forceps or(More)
AIM To determine the feasibility of a multicentre randomised controlled trial (RCT) to investigate whether digital rotation of the fetal head from occiput posterior (OP) position in the second stage of labour reduces the risk of operative delivery (defined as caesarean section (CS) or instrumental delivery). METHODS We conducted the study between December(More)
BACKGROUND Fetal occiput transverse position in the form of deep transverse arrest has long been associated with caesarean section and instrumental vaginal delivery. Occiput transverse position incidentally found in the second stage of labour is also associated with operative delivery in high risk cohorts. There is evidence from cohort studies that(More)
BACKGROUND Medical management of miscarriage allows women to avoid the risks associated with surgical intervention. In 2011 the early pregnancy assessment service (EPAS) at the Royal Prince Alfred Hospital (RPAH) in Sydney, Australia introduced medical management of miscarriage with single-dose 800 μg vaginal misoprostol. AIMS We sought to investigate the(More)
OBJECTIVE To report the complication rate associated with external cephalic version (ECV) at term. DESIGN Single-centre retrospective study. SETTING A major tertiary hospital in Sydney, Australia. POPULATION OR SAMPLE All women who underwent an ECV at Royal Prince Alfred Hospital from 1995-2013 were included. METHODS ECV was attempted on all(More)
BACKGROUND There is global concern about rising caesarean section rates. Identification of risk factors could lead to preventative measures. AIMS To describe the association between neonatal head circumference and (i) caesarean section for failure to progress, (ii) intrapartum caesarean section overall. MATERIALS AND METHODS This was a retrospective(More)
Intrapartum transmission is epidemiologically important for some viruses such as HIV and hepatitis B virus, but its precise mechanism is unknown. We hypothesised that the ability of elective caesarean section to prevent HIV may be due to prevention of transplacental microtransfusions of blood during labour. Their frequency is not known so we performed a(More)
BACKGROUND The use of single-dose intramuscular administration of methotrexate in the treatment of ectopic pregnancies (EP) is a well-established practice. This study evaluates its use at a novel dose of 40 mg/m(2) body surface area (BSA). OBJECTIVE To evaluate the efficacy and safety of single-dose methotrexate treatment 40 mg/m(2) for tubal EP and(More)
OBJECTIVE To evaluate if ultrasound-determined occipito-transverse position early in the second stage of labor is associated with operative delivery. DESIGN Retrospective review of two prospective cohort studies. SETTING An Australian tertiary referral hospital. POPULATION Women with term, cephalic singleton pregnancies. METHODS Retrospective(More)