Bradley T. Christian

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Digital tomosynthesis in breast imaging.

Loren T. Niklason, Bradley T. Christian, +19 authors Rainer Wirth
Radiology
1997

PURPOSE To describe and evaluate a method of tomosynthesis breast imaging with a full-field digital mammographic system. MATERIALS AND METHODS In this tomosynthesis method, low-radiation-dose… (More)

Brain imaging of 18F-fallypride in normal volunteers: blood analysis, distribution, test-retest studies, and preliminary assessment of sensitivity to aging effects on dopamine D-2/D-3 receptors.

Jogeshwar Mukherjee, Bradley T. Christian, +4 authors Joseph Mantil
Synapse
2002

Human studies of dopamine D2/D3 receptors using 18F-fallypride-PET in normal volunteers were performed to evaluate brain distribution in striatal and extrastriatal regions, evaluate metabolites in… (More)

Reliability and precision of pseudo-continuous arterial spin labeling perfusion MRI on 3.0 T and comparison with 15O-water PET in elderly subjects at risk for Alzheimer's disease.

Guofan Xu, Howard A. Rowley, +6 authors Sterling C. Johnson
NMR in biomedicine
2010

Arterial spin labeling (ASL) offers MRI measurement of cerebral blood flow (CBF) in vivo, and may offer clinical diagnostic utility in populations such as those with early Alzheimer's disease (AD).… (More)

Evaluation of Dopamine D-2 Receptor Occupancy by Clozapine, Risperidone, and Haloperidol In Vivo in the Rodent and Nonhuman Primate Brain Using 18F-Fallypride

Jogeshwar Mukherjee, Bradley T. Christian, Tanjore K. Narayanan, Bingzhi Shi, Joseph Mantil
Neuropsychopharmacology
2001

We have used the high-affinity dopamine D-2 receptor radioligand, 18F-fallypride for evaluating receptor occupancy by the antipsychotic drugs, clozapine, risperidone, and haloperidol in rodents and… (More)

Association of Insulin Resistance With Cerebral Glucose Uptake in Late Middle-Aged Adults at Risk for Alzheimer Disease.

Auriel A. Willette, Barbara B. Bendlin, +10 authors Sanjay Asthana
JAMA neurology
2015

IMPORTANCE Converging evidence suggests that Alzheimer disease (AD) involves insulin signaling impairment. Patients with AD and individuals at risk for AD show reduced glucose metabolism, as indexed… (More)

Dynamic PET denoising with HYPR processing.

Bradley T. Christian, Nicholas T. Vandehey, John M Floberg, Charles A. Mistretta
Journal of nuclear medicine : official…
2010

HighlY constrained backPRojection (HYPR) is a promising image-processing strategy with widespread application in time-resolved MRI that is also well suited for PET applications requiring time series… (More)

The effects of normal aging on amyloid-β deposition in nondemented adults with Down syndrome as imaged by carbon 11–labeled Pittsburgh compound B

Patrick J Lao, Tobey J. Betthauser, +17 authors Bradley T. Christian
Alzheimer's & Dementia
2016

INTRODUCTION In Down syndrome (DS), the overproduction of amyloid precursor protein is hypothesized to predispose young adults to early expression of Alzheimer-like neuropathology. METHODS PET… (More)

Cerebrospinal fluid ratios with Aβ42 predict preclinical brain β-amyloid accumulation.

Annie M Racine, Rebecca L. Koscik, +17 authors Sterling C. Johnson
Alzheimer's & dementia
2016

INTRODUCTION Biomarkers are urgently needed for the critical yet understudied preclinical stage of Alzheimer's disease (AD). METHODS CSF collection, [C-11]PiB amyloid imaging, and MRI were acquired… (More)

Prenatal Stress Induces Increased Striatal Dopamine Transporter Binding in Adult Nonhuman Primates

Alexander K. Converse, Colleen F. Moore, +10 authors Mary L. Schneider
Biological Psychiatry
2013

BACKGROUND To determine the effects in adult offspring of maternal exposure to stress and alcohol during pregnancy, we imaged striatal and midbrain dopamine transporter (DAT) binding by positron… (More)

D2/D3 dopamine receptor binding with [F-18]fallypride in thalamus and cortex of patients with schizophrenia

Monte S. Buchsbaum, Bradley T. Christian, +6 authors Jogeshwar Mukherjee
Schizophrenia Research
2006

BACKGROUND Abnormalities in the dopaminergic system are implicated in schizophrenia. [F-18]fallypride is a highly selective, high affinity PET ligand well suited for measuring D2/D3 receptor… (More)

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