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Oxidative stress is a universal phenomenon experienced by organisms in all domains of life. Proteins like those in the ferritin-like di-iron carboxylate superfamily have evolved to manage this stress. Here we describe the cloning, isolation, and characterization of a Dps-like protein from the hyperthermophilic archaeon Pyrococcus furiosus (PfDps-like).… (More)
Three methods of measuring the surface area of the involved skin were compared in 10 patients with psoriasis. Using the rule of nines, four untrained observers estimated the average extent of psoriasis as 20, 14, 23 and 33% of the body surface area. Measuring the area of tracings of plaque outlines using image analysis gave a mean involved surface area of… (More)
One hundred and four consecutive patients with psoriasis who were being treated in two Dublin dermatology hospital units answered a questionnaire. Social and emotional morbidity was present for many patients despite access to modern treatment facilities. Fifty five percent of patients had never experienced a complete remission from their psoriasis. A large… (More)
A case is reported of a patient who developed blistering of the skin followed by ulceration and scarring while on treatment with etretinate.
Primary cutaneous B-cell lymphoma is a low-grade malignancy, distinct from other lymphomas in terms of biological activity and response to treatment. We describe a 77-year-old woman with a five-year history of chronic hepatitis C infection who developed a lower-limb lesion over a period of 3 months which was diagnosed as a high-grade cutaneous B-cell… (More)
We report an elderly woman with rapidly progressive painless, woody induration of the hands. Mild diabetes mellitus was demonstrated. Skin biopsy features included broad fibrous bands extending deeply into subcutaneous fat, a mild mononuclear cell infiltrate, and post-thrombotic recanalization of a deep vessel in one specimen. The patient developed… (More)
Noninvasive isotope chelate methods to assess glomerular filtration rate (GFR) are less accurate than blood sampling. However, some measurement errors would be expected to be constant for an individual, and repeat estimations may be less variable. In 18 patients, estimates of GFR were obtained by 2 gamma camera techniques and a portable external detector at… (More)