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The selective vulnerability of brainstem astrocytes to 1,3-dinitrobenzene is mediated by a 10-fold lower threshold for opening of the cyclosporin A-inhibitable mitochondrial permeability transition pore (mtPTP). BCL-XL, BAX and BCL-2 are members of the BCL-2 protein family known to regulate both apoptotic and necrotic cell death signaling at the mtPTP. The(More)
Executive Officer, SSC, came to the meeting from Geneva. Others present were Keith Lindsay and Phyllis Lee who are engaged in elephant research in Amboseli National Park, Kenya. Matters requiring attention in the next six months were discussed and most of these are now under way. They are either described in the body of this Newsletter or outlined below.(More)
BACKGROUND Pressure wire based fractional flow reserve (FFR) may be used for functional testing of stenosis-mediated ischemia. To further expand the use of physiological lesion assesment, quantitative flow ratio (QFR) based on computation of coronary angiography was recently developed. This is the first adequately powered, prospective study to evaluate the(More)
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