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Injured sensory neuron-derived CSF1 induces microglia proliferation and DAP12-dependent pain
Although microglia have been implicated in nerve injury–induced neuropathic pain, the manner by which injured sensory neurons engage microglia remains unclear. We found that peripheral nerve injuryExpand
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An Epigenetic Signature for Monoallelic Olfactory Receptor Expression
Constitutive heterochromatin is traditionally viewed as the static form of heterochromatin that silences pericentromeric and telomeric repeats in a cell cycle- and differentiation-independent manner.Expand
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Enhancer Interaction Networks as a Means for Singular Olfactory Receptor Expression
The transcriptional activation of one out of ?2800 olfactory receptor (OR) alleles is a poorly understood process. Here, we identify a plethora of putative OR enhancers and study their in vivoExpand
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Alteration of genic 5-hydroxymethylcytosine patterning in olfactory neurons correlates with changes in gene expression and cell identity
The modified DNA base 5-hydroxymethylcytosine (5hmC) is enriched in neurons where it may contribute to gene regulation and cellular identity. To determine how 5hmC influences gene expression in an inExpand
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High-throughput mapping of the promoters of the mouse olfactory receptor genes reveals a new type of mammalian promoter and provides insight into olfactory receptor gene regulation.
The olfactory receptor (OR) genes are the largest mammalian gene family and are expressed in a monogenic and monoallelic fashion in olfactory neurons. Using a high-throughput approach, we mapped theExpand
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Dnmt3a Regulates Global Gene Expression in Olfactory Sensory Neurons and Enables Odorant-Induced Transcription
During differentiation, neurons exhibit a reorganization of DNA modification patterns across their genomes. The de novo DNA methyltransferase Dnmt3a is implicated in this process, but the effects ofExpand
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Soft X-Ray Tomography Reveals Gradual Chromatin Compaction and Reorganization during Neurogenesis In Vivo.
The realization that nuclear distribution of DNA, RNA, and proteins differs between cell types and developmental stages suggests that nuclear organization serves regulatory functions. UnderstandingExpand
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Draft genome assembly of the Bengalese finch, Lonchura striata domestica, a model for motor skill variability and learning
Abstract Background Vocal learning in songbirds has emerged as a powerful model for sensorimotor learning. Neurobehavioral studies of Bengalese finch (Lonchura striata domestica) song, naturally moreExpand
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The dynamic patterning and functional roles of DNA modifications in olfactory sensory neurons
Author(s): Colquitt, Bradley Mark | Advisor(s): Lomvardas, Stavros | Abstract: The dazzling complexity of multicellular organisms is generated from just a single genome, which must be interpretedExpand