Braden J. Manns

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CONTEXT The current staging system for chronic kidney disease is based primarily on estimated glomerular filtration rate (eGFR) with lower eGFR associated with higher risk of adverse outcomes. Although proteinuria is also associated with adverse outcomes, it is not used to refine risk estimates of adverse events in this current system. OBJECTIVE To(More)
CONTEXT Morbidity and mortality rates in hemodialysis patients remain excessive. Alterations in the delivery of dialysis may lead to improved patient outcomes. OBJECTIVE To compare the effects of frequent nocturnal hemodialysis vs conventional hemodialysis on change in left ventricular mass and health-related quality of life over 6 months. DESIGN,(More)
CMAJ • NOVEMBER 18, 2008 • 179(11) © 2008 Canadian Medical Association or its licensors 1154 New guidelines for the management of chronic kidney disease have been developed by the Canadian Society of Nephrology (Appendix 1 contains the fulltext guidelines; available at /full/179/11/1154/DC1). These guidelines describe key aspects of(More)
BACKGROUND Acute kidney injury (AKI) is associated with early mortality after percutaneous coronary revascularization procedures, but its prognostic relevance to long-term clinical outcomes remains controversial. METHODS AND RESULTS We conducted a retrospective study of 14782 adults who received coronary angiography in the province of Alberta, Canada,(More)
CONTEXT Acute renal failure requiring dialytic support is associated with a high risk of mortality and substantial morbidity. OBJECTIVES To summarize current evidence guiding provision of dialysis for patients with acute renal failure, to make recommendations for management, and to identify areas in which additional research is needed. DATA SOURCES(More)
BACKGROUND Care of patients with end-stage renal disease (ESRD) is important and resource intense. To enable ESRD programs to develop strategies for more cost-efficient care, an accurate estimate of the cost of caring for patients with ESRD is needed. METHODS The objective of our study is to develop an updated and accurate itemized description of costs(More)
BACKGROUND Recombinant human activated protein C was shown in the Recombinant Human Activated Protein C Worldwide Evaluation in Severe Sepsis (PROWESS) study to reduce mortality among patients with severe sepsis. A post hoc reanalysis by the Food and Drug Administration (FDA) of data from this study suggested that the reduction in mortality was restricted(More)
CONTEXT National public insurance for drugs is often based on evidence of comparative effectiveness and cost-effectiveness. This study describes how that evidence has been used across 3 jurisdictions (Australia, Canada, and Britain) that have been at the forefront of evidence-based coverage internationally. OBJECTIVES To describe how clinical and(More)
BACKGROUND Accurate prediction of survival for patients with end-stage renal disease (ESRD) and multiple comorbid conditions is difficult. In nondialysis patients, the Charlson Comorbidity Index has been used to adjust for comorbidity. The purpose of this study is to assess the validity of the Charlson index in incident dialysis patients and modify the(More)
From the Departments of Medicine (M.T., N.P.) and Public Health Sciences (M.T.) and the Division of Critical Care Medicine (N.P.), University of Alberta, Edmonton; and the Departments of Medicine and Community Health Sciences, University of Calgary, Calgary, AB (B.M.) — both in Canada. Address reprint requests to Dr. Tonelli at 7-129 Clinical Science Bldg.,(More)