Brad Duerstock

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We have previously shown that acrolein, a lipid peroxidation byproduct, is significantly increased following spinal cord injury in vivo, and that exposure to neuronal cells results in oxidative stress, mitochondrial dysfunction, increased membrane permeability, impaired axonal conductivity, and eventually cell death. Acrolein thus may be a key player in the(More)
Acrolein, an α,β-unsaturated aldehyde and a reactive product of lipid peroxidation, has been suggested as a key factor in neural post-traumatic secondary injury in spinal cord injury (SCI), mainly based on in vitro and ex vivo evidence. Here, we demonstrate an increase of acrolein up to 300%; the elevation lasted at least 2 weeks in a rat SCI model. More(More)
We have studied the ability of nonionic detergents and hydrophilic polymers to seal permeabilized membranes of damaged cells, rescuing them from progressive dissolution, degeneration, and death. We report that a single subcutaneous injection of the tri-block copolymer, Poloxamer 188 (P188) 6 hr after a severe compression of the adult guinea pig spinal cord(More)
ACKNOWLEDGMENTS Throughout the course of my education and research, there have been many in R dividuals who have supported and encouraged my academic development. I would first like to thank my thesis advisor, Professor Chandrajit Bajaj, for his years of guidance in my research and educational activities. His enthusiasm for learning, teaching, and(More)
To the best of my knowledge and as understood by the student in the Thesis/Dissertation Agreement, Publication Delay, and Certification Disclaimer (Graduate School Form 32), this thesis/dissertation adheres to the provisions of Purdue University's " Policy of Integrity in Research " and the use of copyright material. inspirational guidance during my(More)
Initially, human machine interface (HMI) was understood as the hardware and software through which human and machine could communicate. Gradually, is being recognized that many human factors such as usability, emotion, user's physical and cognitive characteristics, domain knowledge, contribute as much to the effectiveness and efficiency of HMIs as robust,(More)
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