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OBJECTIVE Inducible costimulator (ICOS)/B7h costimulation plays a crucial role in acute and chronic allograft rejection. To test the role of the ICOS signal in T-cell activation and expansion, we used ICOS-Fc-targeted B cells as donor antigen presenting cells to challenge the allogeneic response in vitro. METHODS In vitro, the binding of ICOS-Fc with B7h(More)
This article is aimed at the differences in lumbar vertebral three-dimensional movement and in stability between the old and the young people, and at the reasons which lead to the differences. Fifteen fresh adult male cadavers were divided into two groups: the young group, 20-30 years old, comprising 7 cases; the old group, 60-70 years old, 8 caes. Lumbar(More)
In order to further research into the EEG information of rats epileptic model, we applied different nonlinear dynamic methods. After having analyzed the EEG signal of rat falling sickness by means of approximate entropy and correlation dimension, we adopted a the new method, unstable periodic orbits, which was used to analyze complex activity of neurons(More)
OBJECTIVE To investigate apoptosis of the CD8(+) T cells (Tc) subpopulation in rodent cardiac allograft recipients, which were treated by donor specific transfusion combined with blockade of Inducible costimulator (ICOS)/B7 homologous protein (B7h) costimulation. METHODS Donor hearts were heterotopically transplanted into the necks of recipient mice using(More)
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