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OBJECTIVE To investigate the effect of ischemic postconditioning on protein aggregation caused by transient ischemia and reperfusion and to clarify its underlying mechanism. METHODS Two-vessel-occluded transient global ischemia rat model was used. The rats in ischemic postconditioning group were subjected to three cycles of 30-s/30-s reperfusion/clamping(More)
This investigation elucidates the Akt/mitochondrial ATP-sensitive K(+) (mitoK(ATP)) channel signaling pathway in late pharmacological preconditioning, using the mitoK(ATP) channel openers BMS-191095 (BMS) and diazoxide (DE). BMS (1 mg/kg ip) and DE (7 mg/kg ip) alone or BMS plus wortmannin (WTN, 15 microg/kg ip), an inhibitor of phosphatidylinositol(More)
This paper proposes an improved method for generating different phases of visual stimulus while liquid crystal display (LCD)/cathode ray tube (CRT) is employed as the visual stimulator. Since using the traditional method can only generate the limited frequencies and phases of visual stimulus, increasing the number of different flickering targets becomes(More)
To investigate the role of mitochondria in the protective effects of ginsenoside Rb1 on cellular apoptosis caused by oxygen-glucose deprivation, in this study, MTT assay, TUNEL staining, flow cytometry, immunocytochemistry and western blotting were used to examine the cellular viability, apoptosis, ROS level, mitochondrial membrane potential, and the(More)
Gaussian mixture model (GMM) has been considered to model the EEG data for the classification task in brain-computer interface (BCI) system. In the practical BCI application, however, the performance of the classical GMM optimized by standard expectation-maximization (EM) algorithm may be degraded due to the noise and outliers, which often exist in(More)
The effects of early relief of heavy bilateral carotid stenosis and ischemic postconditioning on hippocampus CA1 neurons are still unclear. In this study, we used a rat model to imitate severe bilateral carotid stenosis in humans. The rats were divided into sham group, carotid stenosis group, stenosis relief group and ischemic postconditioning group.(More)
Classification of electroencephalogram (EEG) is a crucial issue for EEG-based brain computer interface (BCI) system. In this paper, the performances of the Gaussian process classifier (GPC) for three different categories of EEG signals, i.e. steady state visually evoked potential (SSVEP), motor imagery and finger movement EEG data, are investigated. The(More)
BACKGROUND AND PURPOSE Complications due to brain edema and breakdown of blood brain barrier are an important factor affecting the treatment effects of patients with severe carotid stenosis. In this study, we investigated the protective effects of ischemic postconditioning on brain edema and disruption of blood brain barrier via establishing rat model of(More)