Boyd M. Knosp

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Allele variants of EYA1 and EYA4, two members of the vertebrate Eya gene family, underlie two types of inherited human deafness, branchio-oto-renal (BOR) syndrome and DFNA10, respectively. To clarify how mutations in these two genes and their encoded proteins impact the normal biology of hearing, we completed a number of functional studies using the(More)
In this study we tested the efficacy of quantitative texture analysis in the identification of acute myocardial ischemia using an ultrasound data acquisition system that digitizes and stores echocardiographic data in polar format. In nine closed-chest dogs, data were acquired before and after coronary occlusion using a 2.4 MHz echocardiographic system.(More)
The UDP-glucuronosyltransferase UGT2B7 is an important human UGT isoform that catalyzes the conjugation of many endogenous and exogenous compounds, among them opioids, resulting in the formation of D-glucuronides. The binding site of the aglycone is located in the N-terminal half of the protein. Using NMR analysis, we demonstrate that the opioid binding(More)
Salmonella enterica serovar Typhimurium causes human gastroenteritis and a systemic typhoid-like infection in mice. Infection is initiated by entry of the bacteria into intestinal epithelial cells and is mediated by a type III secretion system that is encoded by genes in Salmonella pathogenicity island 1. The expression of invasion genes is tightly(More)
Echocardiographic differentiation among intracavitary thrombus, cavity noise, and adjacent myocardium can be difficult. As an initial step toward quantitative thrombus characterization with ultrasound, 11 dogs were studied with an in vivo intracardiac thrombus model to delineate the acoustic properties of acute thrombi. The apical coronary arteries were(More)
This paper illustrates a Multi-Agent system architecture for end-user level Grid monitoring using Geographical Information Systems (MAGGIS). The purpose of this research is to investigate MAGGIS architecture and implementation issues, and to verify the following two hypotheses: 1.) multiagent systems provide an effective and scalable architecture to(More)
Resource discovery technologies for grids and peer-to-peer (P2P) systems share some characteristics. However, some P2P systems such as skip graph cannot simply be applied to grid resource discovery because complex grid resources need to be searched by using multi-attribute queries. This paper proposes a new multi-attribute P2P resource discovery approach(More)
The molecular modeling program SYBYL was used to simulate the adsorption of various barbiturates by an activated charcoal surface. The compounds barbituric acid (BA), barbital (B), phenobarbital (PB), mephobarbital (M), and primidone (Pr) were modeled, and their structures were energetically minimized. These structures agreed with literature reports for the(More)
This paper presents a preliminary study of using MCMS-powered P2P technology to conduct parallel integrations which has been widely used in applied mathematics, sciences and engineering. In this study, we designed a system which allow migrate numerical integrations in a P2P/Grid based environment. The system’s client responses for a job scheduling, domain(More)