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An H3K36 methylation-engaging Tudor motif of polycomb-like proteins mediates PRC2 complex targeting.
Polycomb repressive complex 2 (PRC2) regulates pluripotency, differentiation, and tumorigenesis through catalysis of histone H3 lysine 27 trimethylation (H3K27me3) on chromatin. However, theExpand
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Three Mechanisms of Weight Decay Regularization
TLDR
We show that weight decay exerts a regularization effect, depending on the particular optimization algorithm and architecture: (1) increasing the effective learning rate, approximately regularizing the input-output Jacobian norm, and reducing the effective damping coefficient for second-order optimization. Expand
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Selective inhibition of EZH2 and EZH1 enzymatic activity by a small molecule suppresses MLL-rearranged leukemia.
Enhancer of zeste homolog 2 (EZH2) and related EZH1 control gene expression and promote tumorigenesis via methylating histone H3 at lysine 27 (H3K27). These methyltransferases are ideal therapeuticExpand
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Predicting semantically linkable knowledge in developer online forums via convolutional neural network
TLDR
We formulate the problem of predicting semantically linkable knowledge units as a multiclass classification problem, and solve the problem using deep learning techniques. Expand
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AnswerBot: Automated generation of answer summary to developers' technical questions
TLDR
The prevalence of questions and answers on domain-specific Q&A sites like Stack Overflow constitutes a core knowledge asset for software engineering domain. Expand
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Combining Software Metrics and Text Features for Vulnerable File Prediction
TLDR
In recent years, to help developers reduce time and effort required to build highly secure software, a number of prediction models which are built on different kinds of features have been proposed to identify vulnerable source code files, it analyzes software metrics and text mining together to build a composite prediction model. Expand
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Targeting EZH2 and PRC2 dependence as novel anticancer therapy.
Distinctive patterns of chromatin modification control gene expression and define cellular identity during development and cell differentiation. Polycomb repressive complex 2 (PRC2), the soleExpand
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Question Relatedness on Stack Overflow: The Task, Dataset, and Corpus-inspired Models
TLDR
We analyze the problem of predicting knowledge unit (question thread) relatedness in Stack Overflow, the most popular resource for topics related to software development. Expand
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The Chromatin Remodeler BPTF Activates a Stemness Gene-Expression Program Essential for the Maintenance of Adult Hematopoietic Stem Cells
Summary Self-renewal and differentiation of adult stem cells are tightly regulated partly through configuration of chromatin structure by chromatin remodelers. Using knockout mice, we hereExpand
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