Boudewijn T. H. M. Sleutjes

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UNLABELLED Objective To evaluate an automated method that extracts motor unit (MU) information from the CMAP scan, a high-detail stimulus-response curve recorded with surface EMG. Discontinuities in the CMAP scan are hypothesized to result from MU loss and reinnervation. METHODS We introduce the parameter D50 to quantify CMAP scan discontinuities. D50 was(More)
INTRODUCTION This article is part of the Focus Theme of Methods of Information in Medicine on "Biosignal Interpretation: Ad-vanced Methods for Neural Signals and Images". OBJECTIVES The study discusses a technique to automatically correct for effects of electrode grid displacement across serial surface EMG measurements with high-density electrode arrays(More)
OBJECTIVE To determine and compare the diagnostic accuracy of electrically elicited multiplet discharges (MDs) and fasciculation potentials (FPs) in motor neuron disease (MND). METHODS Patients were eligible when they had MND in their differential diagnosis and were referred for electromyogram (EMG). Stimulated high-density surface EMG of the thenar(More)
OBJECTIVE To determine whether there is a relation between electrically evoked multiplet discharges (MDs) and motor axonal excitability properties. We hypothesized that electrically evoked MDs share their underlying pathophysiological mechanism with fasciculations. METHODS High-density surface EMG and motor nerve excitability recordings of the thenar(More)
INTRODUCTION In some peripheral nervous system disorders, cold induces symptoms of muscle weakness without loss of sensation. To understand this selective effect on motor function, it is first essential to delineate the effects of cooling in motor and sensory axons of healthy subjects. METHODS In 17 healthy volunteers, we performed excitability and(More)
INTRODUCTION The aim of this study was to determine whether electrically evoked multiplet discharges (MDs) are related to severity of clinical deterioration in motor neuron disease (MND). METHODS Stimulated high-density surface electromyographic (HDsEMG) recordings were performed in thenar muscles. Data were collected from 31 MND patients. MDs from the(More)
The purpose of this study was to evaluate the accuracy of two techniques for the continuous assessment of cardiac output in patients with chronic heart failure (CHF): a radial artery pulse contour analysis method that uses an indicator dilution method for calibration (LiDCO) and an impedance cardiography technique (Physioflow), using the Fick method as a(More)
INTRODUCTION Fasciculations, the spontaneous activity of single motor units (MUs) are characteristic, but nonspecific for motor neuron disease (MND). We aimed to identify MU discharge properties to optimally differentiate MND patients from healthy controls. METHODS High-density surface electromyography recordings were performed in the thenar muscles(More)
Continuous assessment of mixed venous oxygen saturation (cSvO2) during exercise using a fiber optic pulmonary artery catheter can provide valuable information on the physiological determinants of the exercise capacity in patients with chronic heart failure (CHF). Since its accuracy is not well established during exercise, this study evaluated the(More)
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