Borje E. Christopher Nordin

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Determining risk is the first step in deciding on appropriate management steoporosis, most simply and elegantly defined as " too little bone in the bone " , is generally the result of progressive bone loss which, for all practical purposes, starts at menopause in women and at about the age of 50 years in men. Because women have a lower bone organ density(More)
A series of consecutive unselected patients with primary breast carcinoma and their age-matched controls were studied for serum CEA in relation to clinical findings. Raised CEA was found in a similar frequency in patients with primary breast cancer (pre- and postoperative) and in the control women: 16%, 11% and 11%, respectively, exceeded the selected upper(More)
Osteoporosis is the index disease for calcium deficiency, just as rickets/osteomalacia is the index disease for vitamin D deficiency, but there is considerable overlap between them. The common explanation for this overlap is that hypovitaminosis D causes malabsorption of calcium which then causes secondary hyperparathyroidism and is effectively the same(More)
BACKGROUND Dietary factors acutely influence the rate of bone resorption, as demonstrated by changes in serum bone resorption markers. Dietary calcium exerts its effect by reducing parathyroid hormone levels while other components induce gut incretin hormones both of which reduce bone resorption markers. The impact of dietary calcium on bone turnover when(More)
In previous publications (Jones et al., 1977; Nordin et al., 1980) we have shown that menopausal symptoms respond well to 15 micrograms of ethinyl oestradiol and rather less well to 5 mg daily of norethisterone. We have not previously established whether even smaller doses of ethinyl oestradiol might be effective or whether combining this preparation with(More)
Histomorphometry has been applied to trabecular bone samples obtained post-mortem from young and old women without known bone disease and to bone biopsy specimens from patients with postmenopausal osteoporosis. Bone volume was significantly lower in the old than young controls and significantly lower again in the osteoporotics. The loss of bone with age(More)