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Among the many issues surrounding the involvement of the cerebellum in motor learning, the relative roles of the cerebellar cortex and cerebellar nuclei in Pavlovian conditioning have been particularly difficult to assess. While previous studies have investigated the effects of cerebellar cortex lesions on the acquisition and retention of conditioned(More)
This study demonstrates that individual animals can concurrently acquire differently timed conditioned eyelid responses using a differential conditioning procedure in which distinctive conditioned stimuli (CSs) are individually paired with an unconditioned stimulus, with each using a different interstimulus interval (ISI). This promotes robust conditioning,(More)
As a preface to the pharmacokinetic analysis of cocaine in pregnant and lactating rats (using oral administration of drug), young Long-Evans rats were used to compare the relative concentrations of cocaine in blood, brain, and liver after administering cocaine by iv or oral routes. Cocaine and its metabolites were determined using 3H-cocaine as a tracer,(More)
BACKGROUND Selective serotonin reuptake inhibitors (SSRIs) have been associated with upper gastrointestinal (GI) bleeding. Given their worldwide use, even small risks account for a large number of cases. This study has been conducted with carefully collected information to further investigate the relationship between SSRIs and upper GI bleeding. METHODS(More)
OBJECTIVE The aim of this study was to assess whether the CYP2C9*2 and/or *3 variants might modify the risk for NSAID-related upper gastrointestinal bleeding (UGIB) in NSAID users. PATIENTS AND METHODS We conducted a multicenter, case-control study in which cases were patients aged more than 18 years with a diagnosis of UGIB, and controls were matched (1(More)
Mrs A, a 68-year-old woman with paranoid schizophrenia, was on long-term psychiatric treatment with long-acting intramuscular zuclopenthixol, quetiapine and alprazolam when, in April 2012, she was diagnosed with right breast infiltrating ductal carcinoma. After starting treatment with letrozole on 4 July, Mrs A progressively developed extrapyramidal(More)
The aim of this paper is to present a new tool to do dialectometry. The program, called " DiaTech " , has been incorporated features of previous programs, and especially by the VDM program created under the direction of H. Goebl, researcher of the Salzburg University. The main goal of the new tool is to motivate Dialectology studies and dialectologists,(More)
After administering cocaine to pregnant and lactating dams in oral dosages ranging from 5 to 90 mg/kg/day, we observed a slight increase in fatalities starting at 60 mg/kg/day, followed by a sharp rise fatalities at higher dosages. Therefore, a dosage near 60 mg/kg/day by the oral route appears to mark a useful threshold between highly lethal dosages and an(More)
Pregnant and lactating Long-Evans rats were treated daily with oral cocaine at a dosage rate of 60 mg/kg/day, which is the highest dosage tolerated during chronic treatment. Brain myelin concentrations were compared in the offspring during early myelination (day 15) and peak myelination (day 20). Body and brain weights in the offspring of cocaine-treated(More)
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