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Mitochondrial morphology is shaped by fusion and division of their membranes. Here, we found that adult myocardial function depends on balanced mitochondrial fusion and fission, maintained by processing of the dynamin-like guanosine triphosphatase OPA1 by the mitochondrial peptidases YME1L and OMA1. Cardiac-specific ablation of Yme1l in mice activated OMA1(More)
BACKGROUND Spain, a Mediterranean country with relatively low rates of coronary heart disease, has a high prevalence of traditional cardiovascular risk factors and is experiencing a severe epidemic of overweight/obesity. We designed the Aragon Workers' Health Study (AWHS) to characterize the factors associated with metabolic abnormalities and subclinical(More)
BACKGROUND In-vivo quantification of cardiac perfusion is of great research and clinical value. The dual-bolus strategy is universally used in clinical protocols but has known limitations. The dual-saturation acquisition strategy has been proposed as a more accurate alternative, but has not been validated across the wide range of perfusion rates encountered(More)
Myocardial fibrosis detected via delayed-enhanced magnetic resonance imaging (MRI) has been shown to be a strong indicator for ventricular tachycardia (VT) inducibility. However, little is known regarding how inducibility is affected by the details of the fibrosis extent, morphology, and border zone configuration. The objective of this article is to(More)
Two authors' names were omitted from the original article, Natalia Trayanova and Michael Miller. The affiliations of Drs. Trayanova and Miller are listed in the amended author list above. The labs of Drs. Trayanova and Miller jointly developed the method used in the original paper to estimate the fiber orientations in each patient's heart. 1 Some fiber(More)
To the Editor: After an acute myocardial infarction (AMI), infarct size quantification is of clinical importance because it correlates with postinfarction mortality and morbidity (1). The gold standard in vivo techniques for infarct size quantification are magnetic resonance imaging and single-photon emission computed tomog-raphy; however, these methods are(More)
Beta-3 adrenergic receptor (β3AR) agonists have been shown to produce vasodilation and prevention of ventricular remodeling in different conditions. Given that these biological functions are critical in pulmonary hypertension (PH), we aimed to demonstrate a beneficial effect of β3AR agonists in PH. An experimental study in pigs (n = 34) with chronic PH(More)
OBJECTIVES To estimate the prevalences of the main groups of congenital anomalies and to assess their trend over time. DESIGN Population-based study of prevalences. SETTING The Basque Country, Spain. PARTICIPANTS All births and all congenital anomalies diagnosed prenatally, at birth or during the first year of age, in all hospitals of the country,(More)
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