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  • S. M. Picksley, Borivoj Vojtesek, Alison Sparks, David Philip Lane
  • Biology, Medicine
  • Oncogene
  • 1994 (First Publication: 1 September 1994)
  • The function of p53 is modulated by binding to a number of cellular and viral proteins, such as MDM2 and SV40 large T antigen. An initial immunochemical characterization of the p53-MDM2 complex in aContinue Reading
  • Petr Muller, Eva Růčková, +4 authors Borivoj Vojtesek
  • Biology, Medicine
  • Oncogene
  • 2013 (First Publication: 1 June 2013)
  • Heat shock proteins Hsp90 and Hsp70 facilitate protein folding but can also direct proteins for ubiquitin-mediated degradation. The mechanisms regulating these opposite activities involve Hsp bindingContinue Reading
  • Kelly A Avery-Kiejda, Xu Dong Zhang, +4 authors Peter Hersey
  • Biology, Medicine
  • Clinical cancer research : an official journal of…
  • 2008 (First Publication: 15 March 2008)
  • PURPOSE Metastatic melanoma is largely unresponsive to DNA-damaging chemotherapy agents, although WTp53 is frequently detected. Several isoforms of p53 have been discovered, some of which inhibit p53Continue Reading