Boris Zhurov

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We investigate the dynamics of a synthetic genetic repressilator with quorum sensing feedback. In a basic genetic ring oscillator network in which three genes inhibit each other in unidirectional manner, an additional quorum sensing feedback loop stimulates the activity of a chosen gene providing competition between inhibitory and stimulatory activities(More)
We model the dynamics of the synthetic genetic oscillator Repressilator equipped with quorum sensing. In addition to a circuit of 3 genes repressing each other in a unidirectional manner, the model includes a phase-repulsive type of the coupling module implemented as the production of a small diffusive molecule-autoinducer (AI). We show that the autoinducer(More)
Timothy V. Pyrkov, Evgeny Getmantsev, Boris Zhurov, Konstantin Avchaciov, Mikhail Pyatnitskiy, Leonid Menshikov, Kristina Khodova, Andrei V. Gudkov, Peter O. Fedichev1,3∗ Gero LLC, 24/2 Novokuznetskaya street, Moscow 119017, Russia 2 Roswell Park Cancer Institute, Buffalo, NY 14263, USA and Moscow Institute of Physics and Technology, 141700, Institutskii(More)
The assumption of the fast binding of transcription factors (TFs) to promoters is a typical point in studies of synthetic genetic circuits functioning in bacteria. Although the assumption is effective for simplifying the models, it becomes questionable in the light of in vivo measurements of the times TF spends searching for its cognate DNA sites. We(More)
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