Boris Shraiman

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BACKGROUND microRNAs (miRNAs) are approximately 21 nucleotide non-coding transcripts capable of regulating gene expression. The most widely studied mechanism of regulation involves binding of a miRNA to the target mRNA. As a result, translation of the target mRNA is inhibited and the mRNA may be destabilized. The inhibitory effects of miRNAs have been(More)
An increasingly large number of bacteriophage genomes are being sequenced each year. What is an efficient experimental and computational procedure to analyze transcription strategies of newly sequenced novel bacteriophages? We address this issue using an example of bacteriophage Xp10, which infects rice pathogen Xanthomonas oryzae. This phage is(More)
Biological functions typically involve complex interacting molecular networks, with numerous feedback and regulation loops. How the properties of the system are affected when one, or several of its parts are modified is a question of fundamental interest, with numerous implications for the way we study and understand biological processes and treat diseases.(More)
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