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This work defines the biophysical mechanism of phosphoregulation of microtubule binding by the kinetochore NDC80 complex. Conformational plasticity of the disordered tail of its Hec1 subunit… Expand
The stability of kinetochore-microtubule (KMT) attachments is finely tuned to drive different mitotic processes. This regulation involves phosphorylation of NDC80 complex, a major component of the… Expand
infectious. The crowded environment in the 100-nm sized viral particle makes it impossible for the AVP proteins to utilise regular three-dimensional diffusion to find the large number of protease… Expand
Proper regulation of dynamic interactions between microtubules and chromosomal kinetochores is vitally important for accurate cell division, but little is known about how such regulation is achieved.… Expand