Boris Guiu

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BACKGROUND We analysed whether the level of human epidermal growth factor receptor-2 (HER-2) amplification significantly influenced either pathological complete response (pCR) or recurrence-free survival (RFS) and overall survival (OS) after trastuzumab-based neoadjuvant therapy. METHODS In all, 99 patients with an HER-2-amplified breast tumour treated(More)
RATIONALE Second-line chemotherapy is disappointing in recurrent high-grade gliomas. Dramatic responses in recurrent high-grade gliomas have been reported in a recent monocentric trial with a novel association combining bevacizumab (anti-VEGF monoclonal antibody agent) and irinitecan. OBJECTIVE To report the experience of the ANOCEF group (French speaking(More)
OBJECTIVE Chordomas are rare primary bone tumors for which surgery is classically the first-line treatment. However, safe margins are often difficult to obtain, so that patients are at risk of local recurrence. Because radiation therapy and systemic chemotherapy show limited effectiveness, we report the use of direct intratumoral chemotherapy (IC) to treat(More)
There is a growing amount of literature regarding diffusion-weighted imaging (DWI) of the liver. The apparent diffusion coefficient (ADC) was introduced in 1986 and is used extensively in studies. However, methods for calculating ADC vary considerably and the value of the ADC strongly depends on the b values chosen for its calculation. Indeed, the ADC(More)
Optimization of chemotherapy effectiveness in metastatic colorectal cancers (mCRC) is a major endpoint to enhance the possibility of curative intent surgery. FOLFIRI3 has shown promising results as second-line chemotherapy for mCRC patients previously exposed to oxaliplatin. The clinical efficacy of FOLFIRI3 was never determined in association with(More)
Carcinomatous meningitis (CM) occurs in 3 to 8% of cancer patients. Patients present with a focal symptom, and multifocal signs are often found following neurological examination. The gold standard for diagnosis remains the demonstration of carcinomatous cells in the cerebrospinal fluid on cytopathological examination. Despite the poor prognosis, palliative(More)
OBJECTIVES The objective of this study was to explore the association between health-related quality of life (HRQoL) and the recommended phase 2 dose in a phase I clinical trial according to the Time to HRQoL deterioration approach (TTD). SETTING This is a phase I dose-escalation trial of transarterial chemoembolisation (TACE) with idarubicin-loaded beads(More)
During percutaneous interventional procedures, the orientation and position and of a needle-like instrument can be constrained relative to the patient's coordinate system using a variety of aiming devices. Physicians align the aiming device in space according to a pre-defined plan and advance the instrument without excessive bending, resulting in a higher(More)