Boris Golman

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The heat and mass transfer was investigated during the falling rate period of spray drying of a slurry droplet. The effect of the porosity of crust layer formed from primary particles during liquid evaporation was studied numerically using the developed mathematical model which takes into account the heat and mass transfer in the core and crust regions, the(More)
In this paper, dissolution characteristics of primary-particles and compressed tablets were investigated by experiments using a mathematical model. For the primary-particle, it was found that the dissolution rate increased with a decrease in the particle size. Assuming that primary-particles of size distribution were of cylindrical shape and that the(More)
Spray drying has recently been exploited to prepare a large variety of high-value particles. The aim of the present paper is to analyze the drying mechanism of slurry droplets consist of nanosized particles in an industrial-scale spray dryer. For this purpose, a mathematical model is developed comprising a comprehensive model for the heat and mass transfer(More)
Ethenzamide solids as a representative active pharmaceutical ingredient (API) were batch-ground by means of a fluidized-bed jet-mill which is a relatively new equipment and promising for production in the pharmaceutical field. Thus, the characteristic grinding mechanism was investigated. As a result, the variation of the residual ratio with grinding time(More)
Continuous grinding kinetics of Ethenzamide powder, as a model active pharmaceutical ingredient (API) was investigated by fluidized-bed jet-milling. Because the oversize fractions after the classification were well fitted by a modified Rosin-Rammler distribution function, an equation of grade efficiency curve was obtained, which was also characteristic of(More)
Milling is a common procedure to improve bioavailability of many active pharmaceutical ingredients (APIs), which typically have low solubility in water. But such micronization can yield an increase in the cohesiveness of particles. Although particle cohesiveness is desirable for tablet strength in the subsequent formulation process, increased particle(More)
An enhanced method was proposed for controlled release of core material using a coating layer of fine permeable particles dispersed in an impermeable wax prepared by dry-based process. A mathematical model was constructed to describe in detail the core material release by diffusion through the connected permeable particles inside the coating layer. The(More)
In pharmaceutical industries, most active pharmaceutical ingredients are poorly water soluble, and therefore milling processes are important to obtain fine particles that can be easily dissolved in the body. However, the main purpose of milling is micronization of particles. From the viewpoint of fine particle preparation in the formulation process, milling(More)
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