Booyeol Choi

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BACKGROUND It is unclear how brain reserve interacts with gender and apolipoprotein E4 (APOE4) genotype, and how this influences the progression of Alzheimer's disease (AD). The association between intracranial volume (ICV) and progression to AD in subjects with mild cognitive impairment (MCI), and differences according to gender and APOE4 genotype, was(More)
AIM We determined if differences in renal function, even within normal levels, influenced hippocampal volume (HCV) and cognition. METHODS Cognitively normal (CN) and mild cognitive impairment (MCI) subjects with eGFR ≥ 60 ml/min/1.73m2 were selected from the ADNI database (N = 1,269) and divided into three groups (eGFR 60-75, 75-90 and ≥90). Associations(More)
BACKGROUND Effective treatments to alleviate depression in Alzheimer's disease (AD) have been scarce. OBJECTIVE To investigate the efficacy and tolerability of escitalopram in the treatment of depression in AD. METHODS In this 12-week randomized, double-blind, placebo-controlled trial with open-label, 12-week extension, AD subjects over 50 years of age,(More)
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