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Biologically active substances from amphibians: preliminary studies on anurans from twenty-one genera of Thailand.
Amphibian skin has been the source of a wide variety of biologically active substances, but less than one-third of the known genera of amphibians have been probed for such active substances. Skins ofExpand
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Anti‐HIV‐1 constituents from Clausena excavata: Part II. carbazoles and a pyranocoumarin
Three carbazole derivatives, O‐methylmukonal (1), 3‐formyl‐2,7‐dimethoxycarbazole (2) and clauszoline J (3), and a pyranocoumarin, clausenidin (4), were isolated from the rhizomes and roots ofExpand
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Coumarins and carbazoles from Clausena excavata exhibited antimycobacterial and antifungal activities.
Four known coumarins, dentatin (1), nor-dentatin (2), clausenidin (3) and xanthoxyletin (5), and six known carbazole derivatives, 3-formylcarbazole (6), mukonal (7), 3-methoxycarbonylcarbazole (8),Expand
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Anti‐HIV‐1 limonoid: first isolation from Clausena excavata
A limonoid, clausenolide‐1‐ethyl ether (1) and two coumarins, dentatin (2) and nor‐dentatin (3), were isolated from Clausena excavata. Limonoid 1 was obtained from the crude ethanol extract of theExpand
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Study on cardiac contractility of cycloeucalenol and cycloeucalenone isolated from Tinospora crispa.
This report describes the isolation of two triterpenes from the stems of Tinospora crispa, namely, cycloeucalenol (1). and cycloeucalenone (2). for the first time. It was found that cycloeucalenolExpand
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Potent antitumor activity of synthetic 1,2-Naphthoquinones and 1,4-Naphthoquinones.
Rhinacanthone (1) and two 1,2-pyranonaphthoquinones (2,3) were synthesized and found to show very potent cytotoxicity against three cancer cell lines (KB, HeLa and HepG(2)) with IC(50) values ofExpand
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First synthesis of 3,16,20-polyoxygenated cholestanes, new cytotoxic steroids from the gorgonian Leptogorgia sarmentosa
Using tigogenin as starting material, (20S)-20-hydroxycholestane-3,6-dione (1), (16S, 20S)-16,20-dihydroxycholestan-3-one (2), (20S)-20-hydroxycholest-1-ene-3,16-dione (3) andExpand
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Transforming rhinacanthin analogues from potent anticancer agents into potent antimalarial agents.
Twenty-six novel naphthoquinone aliphatic esters were synthesized by esterification of 1,4-naphthoquinone alcohols with various aliphatic acids. The 1,4-naphthoquinone alcohols were prepared fromExpand
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Synthesis of cytotoxic novel 9,11-secosterol analogs: Structure/activity studies
In an effort to determine the pharmaceutical utility and the structural requirements for activity against tumor cell lines, 30 novel 9,11-secosterol analogues with different side chains and degreesExpand
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