Bonne M. Thompson

Publications31
h-index13
Citations1,195
Highly Influential Citations51
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Mutation of beta-glucosidase 2 causes glycolipid storage disease and impaired male fertility.
beta-Glucosidase 2 (GBA2) is a resident enzyme of the endoplasmic reticulum thought to play a role in the metabolism of bile acid-glucose conjugates. To gain insight into the biological function of… Expand
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Extraction and analysis of sterols in biological matrices by high performance liquid chromatography electrospray ionization mass spectrometry.
We describe the development of a high performance liquid chromatography mass spectrometry (HPLC-MS) method that allows the identification and quantitation of sterols in mammalian cells and tissues.… Expand
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27-Hydroxycholesterol promotes cell-autonomous, ER-positive breast cancer growth.
To date, estrogen is the only known endogenous estrogen receptor (ER) ligand that promotes ER+ breast tumor growth. We report that the cholesterol metabolite 27-hydroxycholesterol (27HC) stimulates… Expand
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Subcellular organelle lipidomics in TLR-4-activated macrophages1[S]
Lipids orchestrate biological processes by acting remotely as signaling molecules or locally as membrane components that modulate protein function. Detailed insight into lipid function requires… Expand
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A Mouse Macrophage Lipidome*♦
We report the lipidomic response of the murine macrophage RAW cell line to Kdo2-lipid A, the active component of an inflammatory lipopolysaccharide functioning as a selective TLR4 agonist and… Expand
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Cilia-Associated Oxysterols Activate Smoothened.
Primary cilia are required for Smoothened to transduce vertebrate Hedgehog signals, but how Smoothened accumulates in cilia and is activated is incompletely understood. Here, we identify… Expand
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Liver-Derived Signals Sequentially Reprogram Myeloid Enhancers to Initiate and Maintain Kupffer Cell Identity.
Tissue environment plays a powerful role in establishing and maintaining the distinct phenotypes of resident macrophages, but the underlying molecular mechanisms remain poorly understood. Here, we… Expand
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Cryo-EM structure of oxysterol-bound human Smoothened coupled to a heterotrimeric Gi
The oncoprotein Smoothened (SMO), a G-protein-coupled receptor (GPCR) of the Frizzled-class (class-F), transduces the Hedgehog signal from the tumour suppressor Patched-1 (PTCH1) to the… Expand
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Bazedoxifene and conjugated estrogen prevent diet-induced obesity, hepatic steatosis, and type 2 diabetes in mice without impacting the reproductive tract.
Despite the capacity of estrogens to favorably regulate body composition and glucose homeostasis, their use to combat obesity and type 2 diabetes is not feasible, because they promote sex… Expand
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Oxysterols provide innate immunity to bacterial infection by mobilizing cell surface accessible cholesterol
Cholesterol 25-hydroxylase ( CH25H ) is an interferon-stimulated gene that converts cholesterol to the oxysterol 25-hydroxycholesterol (25HC). Circulating 25HC modulates essential immunological… Expand
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