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Cyclooxygenase-2 (COX-2) is a major contributor to the elevation of spinal prostaglandin E2, which augments the processing of nociceptive stimuli following peripheral inflammation, and dynorphin has been shown to have an important role in acute and chronic pain states. Moreover, the transcription factor, nuclear factor-kappa B (NF-kB), regulates the(More)
This paper examines three algorithms to recognize speaker's emotion using the speech signals. Target emotions are happiness, sadness, anger, fear, boredom and neutral state. MLB(Maximum-Likelihood Bayes), NN(Nearest Neighbor) and HMM(Hidden Markov Model) algorithms are used as the pattern matching techniques. In all cases, pitch and energy are used as the(More)
We investigated the complexation ratio of siRNA and plasmid DNA combined with Lipofectamine for the effective delivery of genetic materials. First, the amount of Lipofectamine was varied with a fixed amount of DNA or siRNA to determine in which proportions they would form an optimal combination. Finally, to investigate the effect of DNA or siRNA on the(More)
Albendazole is poorly soluble in water and has low bioavailability. The objective of this study was to improve the solubility of albendazole and optimize preparation of an oral nanoparticle formulation, using chitosan-tripolyphosphate (TPP) nanoparticles. The formulation was prepared by mixing the drug solution in Tween 20 with the chitosan solution. TPP(More)
The purpose of this study was to develop a buccal paclitaxel delivery system using the thermosensitive polymer Pluronic F127 (PF127) and the mucoadhesive polymer polyethylene oxide (PEO). The anticancer agent paclitaxel is usually used to treat ovarian, breast, and non-small-cell lung cancer. To improve its aqueous solubility, paclitaxel was incorporated(More)
The objective of this study was to improve the solubility of albendazole and optimize the preparation of an oral nanoparticle formulation, using β-cyclodextrin (βCD) and chitosan-tripolyphosphate (TPP) nanoparticles. The solubility of albendazole in buffers, surfactants, and various concentrations of acetic acid solution was investigated. To determine drug(More)
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