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Bax Inhibitor-1 Is a pH-dependent regulator of Ca2+ channel activity in the endoplasmic reticulum.

• Hyung-ryong Kim, G Lee, +10 authors Han-jung Chae
• The Journal of biological chemistry
• 2008

In this study, Bax inhibitor-1 (BI-1) overexpression reduces the ER pool of Ca(2+) released by thapsigargin. Cells overexpressing BI-1 also showed lower intracellular Ca(2+) release induced by the… (More)

Antimicrobial Peptides for Therapeutic Applications: A Review

• Min-duk Seo, Hyung-Sik Won, Jihun Kim, Tsogbadrakh Mishig-Ochir, Bong-Jin Lee
• Molecules
• 2012

Antimicrobial peptides (AMPs) have been considered as potential therapeutic sources of future antibiotics because of their broad-spectrum activities and different mechanisms of action compared to… (More)

Systematic peptide engineering and structural characterization to search for the shortest antimicrobial peptide analogue of gaegurin 5.

• Hyung-Sik Won, Soo keung Jung, Hyung Eun Kim, Min-duk Seo, Bong-Jin Lee
• The Journal of biological chemistry
• 2004

As part of an effort to develop new, low molecular mass peptide antibiotics, we searched for the shortest bioactive analogue of gaegurin 5 (GGN5), a 24-residue antimicrobial peptide. Thirty-one kinds… (More)

Functional identification of toxin-antitoxin molecules from Helicobacter pylori 26695 and structural elucidation of the molecular interactions.

• Kyung-Doo Han, Atsushi Matsuura, +7 authors Bong-Jin Lee
• The Journal of biological chemistry
• 2011

Bacterial toxin-antitoxin (TA) systems are associated with many important cellular processes including antibiotic resistance and microorganism virulence. Here, we identify and structurally… (More)

Structural determinants for the membrane interaction of novel bioactive undecapeptides derived from gaegurin 5.

• Hyung-Sik Won, Min-duk Seo, +7 authors Bong-Jin Lee
• Journal of medicinal chemistry
• 2006

Gaegurin 5 is a 24-residue, membrane-active antimicrobial peptide isolated from the skin of an Asian frog, Rana rugosa. We recently reported the antimicrobial activities of two novel undecapeptides… (More)

Structural overview on the allosteric activation of cyclic AMP receptor protein.

• Hyung-Sik Won, Yoo-Sup Lee, Sung-Hee Lee, Bong-Jin Lee
• Biochimica et biophysica acta
• 2009

Cyclic AMP receptor protein (CRP) is a prokaryotic global transcription regulator that controls the expression of nearly 200 genes. The protein, allosterically activated by cAMP binding, binds to DNA… (More)

Action mechanism and structural requirements of the antimicrobial peptides, gaegurins.

• Hyung-Sik Won, Su-Jin Kang, Bong-Jin Lee
• Biochimica et biophysica acta
• 2009

Gaegurins (GGNs) are a family of cationic, alpha-helical, antimicrobial peptides that were isolated from a Korean frog, Glandirana emeljanovi (formerly classified as Rana rugosa) and represent one of… (More)

Structural elucidation of the protein- and membrane-binding properties of the N-terminal tail domain of human annexin II.

• Yoon-Hun Hong, Hyung-Sik Won, Hee-Chul Ahn, Bong-Jin Lee
• Journal of biochemistry
• 2003

The conformational preferences and the solution structure of AnxII(N31), a peptide corresponding to the full-length sequence (residues 1-31) of the human annexin II N-terminal tail domain, were… (More)

Structural and biochemical characterization of HP0315 from Helicobacter pylori as a VapD protein with an endoribonuclease activity

• aJ. M. Kwon, Jihun Kim, +6 authors Bong-Jin Lee
• Nucleic acids research
• 2012

VapD-like virulence-associated proteins have been found in many organisms, but little is known about this protein family including the 3D structure of these proteins. Recently, a relationship between… (More)

Structure of Thermoplasma volcanium Ard1 belongs to N-acetyltransferase family member suggesting multiple ligand binding modes with acetyl coenzyme A and coenzyme A.

• Chao Ma, Chinar Pathak, +5 authors Bong-Jin Lee
• Biochimica et biophysica acta
• 2014

Acetylation and deacetylation reactions result in biologically important modifications that are involved in normal cell function and cancer development. These reactions, carried out by protein… (More)

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