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Antimicrobial Peptides for Therapeutic Applications: A Review
Antimicrobial peptides (AMPs) have been considered as potential therapeutic sources of future antibiotics because of their broad-spectrum activities and different mechanisms of action compared toExpand
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Bax Inhibitor-1 Is a pH-dependent Regulator of Ca2+ Channel Activity in the Endoplasmic Reticulum*
In this study, Bax inhibitor-1 (BI-1) overexpression reduces the ER pool of Ca2+ released by thapsigargin. Cells overexpressing BI-1 also showed lower intracellular Ca2+ release induced by the Ca2+Expand
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Antimicrobial peptides: therapeutic potentials
The increasing appearance of multidrug-resistant pathogens has created an urgent need for suitable alternatives to current antibiotics. Antimicrobial peptides (AMPs), which act as defensive weaponsExpand
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In defence of metric learning for speaker recognition
TLDR
The objective of this paper is 'open-set' speaker recognition of unseen speakers, where ideal embeddings should be able to condense information into a compact utterance-level representation that has small intra-speaker and large inter-speakers distance. Expand
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Structural overview on the allosteric activation of cyclic AMP receptor protein.
Cyclic AMP receptor protein (CRP) is a prokaryotic global transcription regulator that controls the expression of nearly 200 genes. The protein, allosterically activated by cAMP binding, binds to DNAExpand
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Tetraspan TM4SF5-dependent direct activation of FAK and metastatic potential of hepatocarcinoma cells
Summary Transmembrane 4 L six family member 5 (TM4SF5) plays an important role in cell migration, and focal adhesion kinase (FAK) activity is essential for homeostatic and pathological migration ofExpand
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Structural and functional studies of the Mycobacterium tuberculosis VapBC30 toxin-antitoxin system: implications for the design of novel antimicrobial peptides
Toxin-antitoxin (TA) systems play important roles in bacterial physiology, such as multidrug tolerance, biofilm formation, and arrest of cellular growth under stress conditions. To develop novelExpand
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Functional Identification of Toxin-Antitoxin Molecules from Helicobacter pylori 26695 and Structural Elucidation of the Molecular Interactions*
Bacterial toxin-antitoxin (TA) systems are associated with many important cellular processes including antibiotic resistance and microorganism virulence. Here, we identify and structurallyExpand
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Action mechanism and structural requirements of the antimicrobial peptides, gaegurins.
Gaegurins (GGNs) are a family of cationic, alpha-helical, antimicrobial peptides that were isolated from a Korean frog, Glandirana emeljanovi (formerly classified as Rana rugosa) and represent one ofExpand
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Structure, Biology, and Therapeutic Application of Toxin–Antitoxin Systems in Pathogenic Bacteria
Bacterial toxin–antitoxin (TA) systems have received increasing attention for their diverse identities, structures, and functional implications in cell cycle arrest and survival against environmentalExpand
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