Bokyung Park

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In humans, the Crumbs homolog-1 (CRB1) gene is mutated in progressive types of autosomal recessive retinitis pigmentosa and Leber congenital amaurosis. However, there is no clear genotype-phenotype correlation for CRB1 mutations, which suggests that other components of the CRB complex may influence the severity of retinal disease. Therefore, to understand(More)
Bokyung Park,1 Celso Henrique Alves,1 Ditte M. Lundvig,1 Naoyuki Tanimoto,3 Susanne C. Beck,3 Gesine Huber,3 Fabrice Richard,4 Jan Klooster,2 Till F. M. Andlauer,1 Eric C. Swindell,5 Milan Jamrich,6 André Le Bivic,4 Mathias W. Seeliger,3 and Jan Wijnholds1 Departments of 1Neuromedical Genetics and 2Retinal Signal Processing, The Netherlands Institute for(More)
The membrane-associated palmitoylated protein 5 (MPP5 or PALS1) is thought to organize intracellular PALS1-CRB-MUPP1 protein scaffolds in the retina that are involved in maintenance of photoreceptor-Müller glia cell adhesion. In humans, the Crumbs homolog 1 (CRB1) gene is mutated in progressive types of autosomal recessive retinitis pigmentosa and Leber(More)
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