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STUDY OBJECTIVE To evaluate the hemodynamic and electrocardiographic effects of a single dose of commercially available bitter-orange dried-fruit extract, which is increasingly being used in dietary supplements. DESIGN Randomized, double-blind, placebo-controlled, crossover study. SETTING University of Connecticut, Storrs Campus. SUBJECTS Eighteen(More)
BACKGROUND Intravenous magnesium reduces the QTc interval of patients receiving ibutilide. Whether oral magnesium can reduce the QTc interval associated with oral sotalol and dofetilide is not known. This study was undertaken to evaluate the impact of oral magnesium on the QTc interval and whether an inherent intracellular magnesium deficiency exists among(More)
  • Bokyung Min
  • 2013
Vitamin D deficiency is prevalent, primarily due to limited sun exposure, which may be observed in urban areas, or as a result of modern lifestyles. Common myths about vitamin D persist, including that it is mostly obtained from the diet and is only essential for bone and mineral homeostasis. Nonetheless, advances in biomedical science suggest that vitamin(More)
STUDY OBJECTIVE Metabolife 356, an ephedra-containing weight-loss product, substantially increases the corrected QT (QTc) interval. Metabolife Ephedra Free, a similar supplement, contains caffeine and extracts of green tea, garcinia cambogia, and yerba mate. Its electrocardiographic (ECG) effects are not known. Therefore, we sought to determine the effect(More)
STUDY OBJECTIVE To determine the effect of an ephedra-containing thermogenic herbal compound (TrimSpa) on rate-corrected QT (QTc) interval duration and systolic blood pressure. DESIGN Randomized, double-blind, placebo-controlled, crossover, intent-to-treat study. SETTING Student laboratory at a college of pharmacy. SUBJECTS Thirteen healthy volunteers(More)
OBJECTIVES To evaluate the impact of epinephrine, norepinephrine, or placebo on the ventricular fibrillation cycle length (VFCL) and the variability of VFCL (cvVFCL) measurements in implantable cardioverter defibrillator (ICD) patients with or without beta-blockers. METHODS Forty-three patients scheduled for their 6-week post-ICD placement noninvasive(More)
PURPOSE The effect of Metabolife Ephedra-Free on blood pressure (BP) and hemodynamics was studied. METHODS Healthy volunteers were randomly assigned to take a single dose of Metabolife Ephedra-Free or matching placebo and then crossed over to the opposite treatment after a seven-day washout period. BP was measured at baseline and one, three, and five(More)
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