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Naringenin induces apoptosis through downregulation of Akt and caspase-3 activation in human leukemia THP-1 cells.
- J. Park, Cheng-yun Jin, Bok-kyu Lee, Gi-Young Kim, Yung-Hyun Choi, Y. Jeong
- Biology, Medicine
- Food and chemical toxicology : an international…
- 1 December 2008
Evidence is provided that NEGN's pro-apoptotic effect is mediated by the activation of caspases and mitochondria dysfunctions that correlate with the inactivation of the PI3K/Akt pathway in THP-1 cells, which has a strong potential as a therapeutic agent for preventing cancers such as leukemia. Expand
Genetic diversity and relationships between wild and cultivated populations of the sea lettuce, Enteromorpha prolifera, in Korea revialed by RAPD markers
The cultivated populations of Enteromorpha prolifera are genetically depauperate relative to their presumptive progenitor and the domestication process has eroded the level of genetic variation of this species, which is higher than average values for species with similar life history. Expand
Effect of medium milieu on sperm penetration and pronuclear formation of bovine oocytes matured in vitro.
The study suggests that fertilization ability of spermatozoa in vitro appears to be more stable in high concentrations of NaCI, because oocytes are more sensitive to osmotic stress than spermatoza, and bicarbonate may be needed mainly for the penetration of spermutozoa. Expand
Genetic Diversity and Population Structure of Liriope platyphylla (Liliaceae) in Korea
An indirect estimate of the number of migrants per generation indicates that gene flow is high among Korean populations of the species and analysis of fixation indices revealed a substantial heterozygosity deficiency in some populations and at some loci. Expand
Genetic diversity and phylogenetic relationships in five Porphyra species revealed by rapd analysis
An indirect estimate of the number of migrants per generation indicated that gene flow was very low among the populations studied, and the classification of Porphyra species based on the DNA markers does not fully coincide with the classification based on morphology. Expand
Effect of Co-Culture with Mammalian Spermatozoa on Maturation in vitro of Porcine Cumulus-Free Germinal Vesicle Oocytes
The purpose of this study was to determine if the addition of spermatozoa into the culture medium could influence the nuclear maturation of denuded porcine germinal vesicle (GV) oocytes in vitro.… Expand
Ecological and Genetic Biodiversity of Corbicula leana in the Nakdong River and the Nam River
The genetic diversity trends to increase from the source of the main river to the mouth of this river suggests that the population of downstream might be expanded toward upstream. Expand
Morphological Variability of the Japanese Swimming Charybdis japonica Populations
Anticancer Activity of Ethanol Extract from Peel of Citrus junos and Poncirus trifoliata on MCF-7 Breast Cancer Cells
The proliferation of MCF-7 breast cancer cells was decreased in a dose-dependent manner treated with various concentration of CJP and PTP, and when compared with the control at 300 mg/ml, the proliferation of the MCf-7 Breast cancer cells of both extracts was decreased over 70% and 80%, respectively. Expand
Genetic Diversity of Sorbus commixta Based on RAPD Markers